Clinical Characteristics and Cardiovascular Magnetic Resonance Findings in Stress (Takotsubo) Cardiomyopathy
Clinical Characteristics and Cardiovascular Magnetic Resonance Findings in Stress (Takotsubo) Cardiomyopathy
复制标题
DOI：
10.1001/jama.2011.992
复制
发表时间：
2011-07-20
影响因子：
120.7
通讯作者：
Friedrich, Matthias G.
中科院分区：
文献类型：
--
作者：
Eitel, Ingo;von Knobelsdorff-Brenkenhoff, Florian;Friedrich, Matthias G.
应激性心肌病 (SC) 是一种由应激事件引发的短暂性急性心力衰竭，与独特的左心室 (LV) 收缩模式相关。其临床特征的各个方面已在小型单中心人群中得到描述，但迄今为止缺乏更大的多中心数据集。此外，入院时仍难以快速做出诊断。 目的 全面定义大量 SC 的临床谱和演变，包括心血管磁共振 (CMR) 成像的组织特征数据；并建立一套适合急性疑似 SC 患者诊断决策的 CMR 标准。2005 年 1 月至 2010 年 10 月期间，在欧洲和北美的 7 个三级护理中心进行了设计、环境和患者前瞻性研究，对 256 名 SC 患者在就诊时以及急性事件后 1 至 6 个月进行了评估。主要结果指标 左心室功能障碍完全恢复。结果 81% 的患者 (n=207) 是绝经后女性，8% (n=20) 是年轻女性（年龄
Context Stress cardiomyopathy (SC) is a transient form of acute heart failure triggered by stressful events and associated with a distinctive left ventricular (LV) contraction pattern. Various aspects of its clinical profile have been described in small single-center populations, but larger, multicenter data sets have been lacking so far. Furthermore, it remains difficult to quickly establish diagnosis on admission.Objectives To comprehensively define the clinical spectrum and evolution of SC in a large population, including tissue characterization data from cardiovascular magnetic resonance (CMR) imaging; and to establish a set of CMR criteria suitable for diagnostic decision making in patients acutely presenting with suspected SC.Design, Setting, and Patients Prospective study conducted at 7 tertiary care centers in Europe and North America between January 2005 and October 2010 among 256 patients with SC assessed at the time of presentation as well as 1 to 6 months after the acute event.Main Outcome Measures Complete recovery of LV dysfunction.Results Eighty-one percent of patients (n=207) were postmenopausal women, 8% (n=20) were younger women (aged