Heterodyne frequency-domain multispectral diffuse optical tomography of breast cancer in the parallel-plane transmission geometry.
Heterodyne frequency-domain multispectral diffuse optical tomography of breast cancer in the parallel-plane transmission geometry.
复制标题
DOI：
10.1118/1.4953830
复制
发表时间：
2016-07
期刊：
影响因子：
3.8
通讯作者：
H. Ban;M. Schweiger;Venkaiah C. Kavuri;J. Cochran;Long Xie;David R. Busch;Jaka Katrasnik;S. Pathak;So Hyun Chung;Kijoon Lee;R. Choe;B. Czerniecki;S. Arridge;Arjun G. Yodh
中科院分区：
文献类型：
--
作者：
H. Ban;M. Schweiger;Venkaiah C. Kavuri;J. Cochran;Long Xie;David R. Busch;Jaka Katrasnik;S. Pathak;So Hyun Chung;Kijoon Lee;R. Choe;B. Czerniecki;S. Arridge;Arjun G. Yodh
作者介绍了一种最先进的全光学临床扩散光学断层扫描（DOT）成像仪器，该仪器在平行板几何结构中收集空间密集、多光谱、频域乳腺数据。方法该仪器采用基于CCD的外差检测方案，允许大量源-检测器对的漫射光子密度波振幅和相位的大规模并行检测（10（6））。因此，独立的临床DOT仪器提供了高空间分辨率，降低了吸收和散射之间的串扰。其他新功能包括条纹轮廓测量系统的乳房边界分割，实时数据标准化，和病人床的设计，允许轴向和矢状乳房测量。结果：作者使用具有两个不同含发色团目标和一个散射目标的组织模拟体模验证了该仪器。作者还在乳腺癌患者的病例研究中展示了该仪器;内源性发色团和散射的重建3D图像给出了与MRI一致的肿瘤定位。结论：采用一种新型平行板DOT乳腺成像仪进行成像，该成像仪在频域中采用高度平行、高分辨率CCD检测。
PURPOSE The authors introduce a state-of-the-art all-optical clinical diffuse optical tomography (DOT) imaging instrument which collects spatially dense, multispectral, frequency-domain breast data in the parallel-plate geometry. METHODS The instrument utilizes a CCD-based heterodyne detection scheme that permits massively parallel detection of diffuse photon density wave amplitude and phase for a large number of source-detector pairs (10(6)). The stand-alone clinical DOT instrument thus offers high spatial resolution with reduced crosstalk between absorption and scattering. Other novel features include a fringe profilometry system for breast boundary segmentation, real-time data normalization, and a patient bed design which permits both axial and sagittal breast measurements. RESULTS The authors validated the instrument using tissue simulating phantoms with two different chromophore-containing targets and one scattering target. The authors also demonstrated the instrument in a case study breast cancer patient; the reconstructed 3D image of endogenous chromophores and scattering gave tumor localization in agreement with MRI. CONCLUSIONS Imaging with a novel parallel-plate DOT breast imager that employs highly parallel, high-resolution CCD detection in the frequency-domain was demonstrated.