The lung cancer database project at the National Cancer Center, Japan: Study design, corresponding rate and profiles of cohort
The lung cancer database project at the National Cancer Center, Japan: Study design, corresponding rate and profiles of cohort
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DOI：
10.1093/jjco/hyl015
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发表时间：
2006-05-01
影响因子：
2.4
通讯作者：
Nishiwaki, Yutaka
中科院分区：
文献类型：
--
作者：
Nakaya, Naoki;Goto, Koichi;Nishiwaki, Yutaka
背景资料：肺癌数据库项目于1999年在日本国立癌症中心医院东建立，作为一个正在进行的项目，以整合肺癌患者各种因素的数据。该项目的目的是建立一个大规模的肺癌登记，将有助于基础研究和临床研究在future.Methods：1999年7月至2004年7月，连续肺癌患者被招募到这个项目。基线调查包括关于各种人口学数据、健康习惯和心理因素的自填问卷。从患者的病历中获得医疗信息。结果：在2506例被要求参加该项目的患者中，有2036例（81%）是新诊断的、未经治疗的原发性肺癌患者。最终分析队列包括1995例患者。几乎所有的1995例患者（相应的比率，99%）完成了人口统计学数据和健康习惯的问卷调查。心理因素问卷和饮食习惯问卷的符合率分别为99%和94%。在后续调查进行，以确定生命状态，截至2004年12月，共有1051例（53%）死亡，44例（2%）失访。结论：本文概述了启动肺癌数据库项目，日本的理由。这个数据库应该被证明是有用的研究人员检查肺癌的发病机制，并可能有助于制定一个框架的癌症治疗。
Background: The lung cancer database project was established in 1999 at the National Cancer Center Hospital East, Japan, as an ongoing project to integrate data on various factors in lung cancer patients. The aim of the project was to construct a large-scale cancer registry for lung cancer that would contribute to basic research and clinical research in the future.Methods: Between July 1999 and July 2004, consecutive lung cancer patients were recruited into this project. The baseline survey consisted of self-administered questionnaires concerning various demographic data, health habits and psychological factors. Medical information was obtained from the patients' medical charts. Urine specimens and blood samples were collected, and DNA was extracted from blood lymphocytes.Results: Out of the 2506 patients who were asked to participate in the project, 2036 (81%) patients with newly diagnosed, untreated primary lung cancer were enrolled. The final analytic cohort consisted of 1995 patients. Virtually all of the 1995 patients (corresponding rate, 99%) completed the questionnaires on demographic data and health habits. The corresponding rates for the questionnaires on psychological factors and dietary habits were 99 and 94%, respectively. In a follow-up survey conducted to determine vital status as of December 2004, a total of 1051 patients (53%) had died and 44 patients (2%) were lost to follow-up.Conclusions: This paper overviews the rationale for initiating the lung cancer database project, Japan. This database should prove useful for researchers examining the pathogenesis of lung cancer and may contribute to the formulation of a framework for cancer treatment.