Clinicopathological significance of vascular endothelial growth factor-C in breast carcinoma with long-term follow-up
Clinicopathological significance of vascular endothelial growth factor-C in breast carcinoma with long-term follow-up
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DOI：
10.1097/01.mp.0000062858.98295.9f
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发表时间：
2003-04-01
期刊：
影响因子：
7.5
通讯作者：
Kakudo, K
中科院分区：
文献类型：
--
作者：
Nakamura, Y;Yasuoka, H;Kakudo, K
肿瘤中血管生成因子和淋巴管生成因子的表达可能影响转移扩散的途径。血管生成因子血管生长因子-C(VEGF-C)参与淋巴管的发育和促进淋巴转移。本研究的目的是确定血管内皮生长因子-C是否与淋巴结转移或预后有关。我们用免疫组织化学方法检测了123例有长期随访的浸润性乳腺癌组织中血管内皮生长因子-C的表达。评估血管内皮生长因子-C的表达与淋巴结状态和其他已建立的临床病理参数之间的关系。此外，还研究了血管内皮生长因子-C的表达是否对乳腺癌的预后有影响。103例(83.7%)有VEGF-C表达。血管内皮生长因子-C阳性表达与淋巴结转移显著相关(P=0.0131)。生存曲线经Kaplan-Meier法和单因素分析显示，阳性表达与无瘤生存期(P=0.0165)和总生存期(P=0.0175)有关。根据我们的研究结果，血管内皮生长因子-C在乳腺癌的淋巴转移中起着关键作用，并且可能是乳腺癌患者长期生存的一个重要预后因素。
Expression of angiogenic and lymphanglogenic factors by tumors may influence the route of metastatic spread. The angiogenic factor vascular growth factor-C (VEGF-C) is implicated hi the development of lymphatic vessels and promotion of lymphatic metastasis. The purpose of this study was to determine whether VEGF-C correlates with lymph node metastasis or prognosis. We assessed VEGF-C expression using immunohistochemistry in 123 invasive breast carcinomas with long-term follow-up. The relationship between VEGF-C expression and lymph node status and other established clinicopathological parameters was assessed. Whether VEGF-C expression plays a prognostic role in breast cancer was also investigated. VEGF-C expression was identified in 103 cases (83.7%). Positive VEGF-C was significantly correlated with lymph node metastasis (P = 0.0131). Survival curves determined by the Kaplan-Meier method and univariate analysis demonstrated that positive VEGF-C was associated with both disease-free survival (P = 0.0165) and overall survival (P = 0.0175). On the basis of our findings, VEGF-C plays a crucial role in lymph node metastasis and may be a significant prognostic factor for long-term survival in breast cancer.