Pathogenesis of human immunodeficiency virus-induced neurological disease
Pathogenesis of human immunodeficiency virus-induced neurological disease
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DOI：
10.1080/13550280390194073
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发表时间：
2003-04-01
影响因子：
3.2
通讯作者：
González-Scarano, F
中科院分区：
文献类型：
--
作者：
Albright, AV;Soldan, SS;González-Scarano, F
1 型人类免疫缺陷病毒 (HIV-1) 感染中枢神经系统通常会导致许多神经损伤，最严重的形式是 HIV 相关痴呆 (HAD)。尽管采用高效抗逆转录病毒治疗 (HAART)，但与 HAD 病理相关的 HIV 脑炎 (HIVE) 仍然持续存在，这凸显了继续关注 HIV 神经生物学研究的重要性。为了阐明HIV神经发病机制的直接和间接机制，目前的研究集中在神经侵袭、HIV-1介导的神经元损伤和细胞凋亡的机制以及大脑中病毒的区室化进化。本综述的目的是对 HIV 神经生物学的最新研究进行选择性概述，仅对既定原则进行简要介绍。
Infection of the central nervous system by the type 1 human immunodeficiency virus (HIV-1) commonly results in a number of neurological impairments known, in their most severe form, as HIV-associated dementia ( HAD). The persistence of HIV encephalitis ( HIVE), the pathological correlate of HAD, in spite of highly active antiretroviral therapy ( HAART) underscores the importance of continued research focused on the neurobiology of HIV. To elucidate direct and indirect mechanisms of HIV neuropathogenesis, current investigation is focused on neuroinvasion, HIV-1 -mediated mechanisms of neuronal damage and apoptosis, and compartmentalized evolution of virus in the brain. The aim of this review is to provide a selective overview of the most recent research on the neurobiology of HIV, adding only a brief introduction regarding established principles.