Common mental disorders in young adults born late-preterm
Common mental disorders in young adults born late-preterm
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DOI：
10.1017/s0033291716000830
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发表时间：
2016-07-01
影响因子：
6.9
通讯作者：
Raikkonen, K.
中科院分区：
文献类型：
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作者：
Heinonen, K.;Kajantie, E.;Raikkonen, K.
背景。晚期早产儿（34 + 0-36 + 6 周 + 妊娠天数）的成年心理健康结果是混合的，并且基于国家登记。我们通过诊断访谈检查了晚期早产是否与成年后常见精神障碍的较高风险相关，以及这种风险是否随着胎龄的增加而降低。方法。共有 800 名出生于 1985 年至 1986 年的年轻人（平均年龄 = 25.3，S.D. = 0.62 岁）参与了 Arvo Ylpp 纵向研究的后续研究。使用综合国际诊断访谈（慕尼黑版本）定义了过去 12 个月内的常见精神障碍（情绪、焦虑和药物滥用障碍）。孕龄从医院出生记录中提取，分为早期早产（< 34 + 0，n = 37）、晚期早产（34 + 0-36 + 6，n = 106）、足月（37 + 0-41 + 6，n = 617）和足月后（542 + 0，n = 40）。结果。晚产儿和足月出生的人患任何常见精神障碍的风险相似[比值比 (OR) 1.11，95% 置信区间 (CI) 0.67-1.84]、情绪（OR 1.11，95% CI 0.54-2.25）、焦虑（OR 1.00，95% CI 0.40-2.50）和物质使用（OR 1.31， 95% CI 0.74-2.32）疾病，以及这些疾病的共病（p = 0.38）。虽然精神障碍风险随着胎龄的增加而显着降低，但这一趋势是由早产儿的风险较高推动的。结论。通过使用在高级新生儿和幼儿护理期间出生的队列，我们发现并非所有早产儿在成年后都面临常见精神障碍的风险 - 晚产儿则不然，而早产儿则面临更高的风险。用于预防和干预的可用资源应针对最早出生的早产群体。
Background. Results of adulthood mental health of those born late-preterm (34 + 0-36 + 6 weeks + days of gestation) are mixed and based on national registers. We examined if late-preterm birth was associated with a higher risk for common mental disorders in young adulthood when using a diagnostic interview, and if this risk decreased as gestational age increased.Method. A total of 800 young adults (mean = 25.3, S. D. = 0.62 years), born 1985-1986, participated in a follow-up of the Arvo Ylpp Longitudinal Study. Common mental disorders (mood, anxiety and substance use disorders) during the past 12 months were defined using the Composite International Diagnostic Interview (Munich version). Gestational age was extracted from hospital birth records and categorized into early-preterm (< 34 + 0, n = 37), late-preterm (34 + 0-36 + 6, n = 106), term (37 + 0-41 + 6, n = 617) and post-term (542 + 0, n = 40).Results. Those born late-preterm and at term were at a similar risk for any common mental disorder [odds ratio (OR) 1.11, 95% confidence interval (CI) 0.67-1.84], for mood (OR 1.11, 95% CI 0.54-2.25), anxiety (OR 1.00, 95% CI 0.40-2.50) and substance use (OR 1.31, 95% CI 0.74-2.32) disorders, and co-morbidity of these disorders (p = 0.38). While the mental disorder risk decreased significantly as gestational age increased, the trend was driven by a higher risk in those born early-preterm.Conclusions. Using a cohort born during the advanced neonatal and early childhood care, we found that not all individuals born preterm are at risk for common mental disorders in young adulthood - those born late-preterm are not, while those born early-preterm are at a higher risk. Available resources for prevention and intervention should be targeted towards the preterm group born the earliest.