Dietary pattern and antioxidants in plasma and erythrocyte in patients with mild cognitive impairment from China.
Dietary pattern and antioxidants in plasma and erythrocyte in patients with mild cognitive impairment from China.
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DOI：
10.1016/j.nut.2015.08.004
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发表时间：
2016-02
期刊：
影响因子：
4.4
通讯作者：
Linhong Yuan;Jinmeng Liu;Weiwei Ma;Li-Kou Dong;Wenjuan Wang;Ruiwen Che;R. Xiao
中科院分区：
文献类型：
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作者：
Linhong Yuan;Jinmeng Liu;Weiwei Ma;Li-Kou Dong;Wenjuan Wang;Ruiwen Che;R. Xiao
目的氧化应激和不健康的饮食模式可能与轻度认知功能障碍（MCI）患者发展为阿尔茨海默病的风险有关。我们探讨了中国老年人的饮食模式，血浆和红细胞抗氧化剂水平和认知功能之间的关联。共招募了138名MCI患者和138名年龄和性别匹配的健康受试者（年龄从55岁到75岁）。膳食调查采用食物频率问卷法。采集外周血和晨点尿进行参数检测。老年人的认知功能通过蒙特利尔认知评估测试进行测量。使用试剂盒测定血浆、红细胞和尿液样品中的抗氧化参数。结果MCI患者血浆总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇均低于对照组（P < 0.01），血浆总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇均低于对照组（P< 0.01）。MCI组每日鱼摄入量低于对照组，红肉摄入量高于对照组（P< 0.05）。MCI组血浆总抗氧化能力、α-生育酚水平较对照组低，丙二醛水平较对照组高（P< 0.05）。MCI组血浆黄酮类化合物浓度、红细胞抗氧化酶活性、尿8-羟基脱氧鸟苷含量与对照组无显著性差异结论高脂血症患者血浆高密度脂蛋白胆固醇、总抗氧化能力和α-生育酚水平降低，少吃鱼多吃红肉的饮食模式可能会导致中国老年人的认知障碍。
ObjectivesOxidative stress and unhealthy dietary patterns are might correlate with the risk of mild cognitive impairment (MCI) patients to develop Alzheimer's disease. We explored the association between dietary pattern, plasma and erythrocyte antioxidants levels, and cognitive function in the older Chinese adults.MethodsThe present study is a case-control study. A total of 138 MCI patients and 138 age- and sex-matched healthy subjects (aged from 55 to 75) were recruited. A food frequency questionnaire method was used for the dietary survey. Peripheral blood and morning spot urine were sampled for parameters detection. Cognitive function of the old subjects was measured by using the Montreal Cognitive Assessment test. Antioxidant parameters in plasma, erythrocyte, and urine samples were measured by using the assay kits. Plasma retinol, α-tocopherol, and flavonoids contents were detected by using high performance liquid chromatography and liquid chromatography mass spectrometer methods respectively.ResultsThe MCI patients had lower plasma total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol than control subjects (P< 0.01). MCI patients consumed less fish and more red meat daily than the controls (P< 0.05). Comparing with controls, lower plasma total antioxidant capacity, α-tocopherol, and higher level of malondialdehyde were detected in the MCI patients (P< 0.05). No significant difference of plasma flavonoids concentration, erythrocyte antioxidant enzyme activities, and urinary 8-hydroxy-2’-deoxyguanosine content was detected among the MCI and control subjects (P> 0.05).ConclusionsLower plasma concentration of high-density lipoprotein cholesterol, total antioxidant capacity, and α-tocopherol levels, and a dietary pattern that is low in fish and high in red meat might contribute to the cognition impairment in older Chinese adults.