Perfusion measurement of the whole upper abdomen of patients with and without liver diseases: Initial experience with 320-detector row CT
Perfusion measurement of the whole upper abdomen of patients with and without liver diseases: Initial experience with 320-detector row CT
复制标题
DOI：
10.1016/j.ejrad.2011.10.009
复制
发表时间：
2012-10-01
影响因子：
3.3
通讯作者：
Sugimura, Kazuro
中科院分区：
文献类型：
--
作者：
Kanda, Tomonori;Yoshikawa, Takeshi;Sugimura, Kazuro
目的：报道320排螺旋CT（CTP）上腹部灌注测量对肝脏疾病及疗效评估的初步经验。有2例肝转移，2例血管瘤，4例肝硬化（疾病组）。4例肝硬化或肝细胞癌（HCC）患者治疗后重复CTP。计算肝动脉和门脉灌注（HAP和HPP）和动脉灌注分数（APF），以及胰腺、脾、胃和门脉内HCC的动脉灌注（AP）。对于无病患者（正常组），比较肝段之间以及胰腺和胃部分之间的值。结果：正常组除肝3段、肝5段、胃底、胃窦APF有显著性差异外，其余均无显著性差异。疾病组的平均HAP和APF显著高于正常组。部分脾栓塞或经颈静脉肝内门体分流术后APF增加。结论：320层螺旋CT可用于测量整个上腹部的血流灌注。我们的初步结果表明，估计灌注值有可能用于评估肝脏疾病和治疗效果。(C)2011爱思唯尔爱尔兰有限公司保留所有权利。
Objectives: To report initial experience of upper abdominal perfusion measurement with 320-detector row CT (CTP) for assessment of liver diseases and therapeutic effects.Materials and methods: Thirty-eight patients who were suspected of having a liver disease underwent CTP. There were two patients with liver metastases, two with hemangiomas, and four with cirrhosis (disease group). CTP was repeated for four patients with cirrhosis or hepatocellular carcinoma (HCC) after therapy. Hepatic arterial and portal perfusion (HAP and HPP) and arterial perfusion fraction (APF), and arterial perfusion (AP) of pancreas, spleen, stomach, and intra-portal HCC were calculated. For disease-free patients (normal group), the values were compared among liver segments and among pancreatic and gastric parts. The values were compared between groups and before and after therapy.Results: No significant differences were found in the normal group except between APFs for liver segments 3 and 5, and fundus and antrum. Mean HAP and APF for the disease group were significantly higher than for the normal group. APF increased after partial splenic embolization or creation of a transjugular intrahepatic portosystemic shunt. HPP increased and AP of intra-portal HCC decreased after successful radiotherapy.Conclusions: 320-Detector row CT makes it possible to conduct perfusion measurements of the whole upper abdomen. Our preliminary results suggested that estimated perfusion values have the potential to be used for evaluation of hepatic diseases and therapeutic effects. (C) 2011 Elsevier Ireland Ltd. All rights reserved.