Serum tocopherol levels and vitamin E intake are associated with lung function in the normative aging study
Serum tocopherol levels and vitamin E intake are associated with lung function in the normative aging study
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DOI：
10.1016/j.clnu.2015.01.020
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发表时间：
2016-02-01
影响因子：
6.3
通讯作者：
Litonjua, Augusto A.
中科院分区：
文献类型：
--
作者：
Hanson, Corrine;Lyden, Elizabeth;Litonjua, Augusto A.
背景与目的：维生素E摄入量与肺功能之间关系的研究结果相互矛盾。本研究旨在评估的影响，维生素E的摄入量和血清水平的生育酚异构体对肺功能的横断面样本的580名男子从规范的老化研究，纵向老化study.Methods：回归模型被用来看看在调整混杂因素后，血清生育酚异构体水平和维生素E摄入量与肺功能参数的关联。维生素E的摄入量采用食物频率问卷和血清水平的γ，α，和δ-生育酚水平进行了测量，采用高效液相chromatography.Results：调整潜在的混杂因素后，血清γ-生育酚与用力肺活量有显着的负相关（β =-0.10，p = 0.05）。α和δ-生育酚与任何肺功能参数无关。在根据阻塞性肺疾病全球倡议（GOLD）分期标准对COPD状态进行分类后，患有更严重COPD的参与者的血清δ-生育酚水平较低（p = 0.01）。在吸烟水平较高的参与者中，血清δ-生育酚水平也较低（p = 0.02）。维生素E摄入量（β = 0.03，p = 0.02; β = 0.03，p = 0.01）和维生素E补充剂的使用（β = 0.05，p = 0.03; β = 0.06。p = 0.02）与FEV 1和FVC呈正相关。服用维生素E补充剂的受试者有显着较高的α-生育酚水平（p < 0.0001）和较低的γ-生育酚水平（p < 0.0001）比non-users.Conclusion：在这项研究中，饮食中的维生素E摄入量和肺功能之间存在正相关，并有证据表明血清中γ-生育酚水平和肺功能之间存在负相关关系。(C)2015 Elsevier Ltd和欧洲临床营养与代谢学会。All rights reserved.
Background & aims: The results of studies assessing relationships between vitamin E intake and status and lung function are conflicting. This study aimed to evaluate the effect of vitamin E intake and serum levels of tocopherol isoforms on lung function in a cross-sectional sample of 580 men from the Normative Aging Study, a longitudinal aging study.Methods: Regression models were used to look at associations of serum tocopherol isoform levels and vitamin E intake with lung function parameters after adjustment for confounders. Vitamin E intake was measured using a food frequency questionnaire and serum levels of gamma, alpha, and delta-tocopherol levels were measured using high-performance liquid chromatography.Results: After adjustment for potential confounders, serum gamma-tocopherol had a significant inverse association with forced vital capacity ((beta = -0.10, p = 0.05). Alpha and delta-tocopherol were not associated with any lung function parameter. After classifying COPD status according to Global Initiative for Obstructive Lung Disease (GOLD) stage criteria, serum levels of delta-tocopherol were lower in participants with more severe COPD (p = 0.01). Serum levels of delta-tocopherol were also lower in participants with greater levels of smoking (p = 0.02). Both vitamin E intake (beta = 0.03, p = 0.02; (3 = 0.03, p = 0.01) and use of vitamin E supplements (beta = 0.05, p = 0.03; beta = 0.06. p = 0.02) were positively associated with FEV1 and FVC, after adjusting for confounders. Subjects who took vitamin E supplements had significantly higher alpha-tocopherol levels (p < 0.0001) and lower gamma-tocopherol levels (p < 0.0001) than non-users.Conclusion: In this study, there is a positive association between dietary vitamin E intake and lung function, and evidence of an inverse relationship between serum levels of gamma-tocopherol and lung function. (C) 2015 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.