A PRACTICAL APPROACH TO DETERMINE DOSE METRICS FOR NANOMATERIALS
A PRACTICAL APPROACH TO DETERMINE DOSE METRICS FOR NANOMATERIALS
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DOI：
10.1002/etc.2878
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发表时间：
2015-05-01
影响因子：
4.1
通讯作者：
Park, Margriet V. D. Z.
中科院分区：
文献类型：
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作者：
Delmaar, Christiaan J. E.;Peijnenburg, Willie J. G. M.;Park, Margriet V. D. Z.
传统上，给药质量用于描述毒性研究中常规化学物质的剂量。为了推导纳米材料的毒性剂量，质量和化学成分本身可能不足以描述剂量，因为具有相同化学成分的颗粒可能具有完全不同的毒性质量剂量，这取决于颗粒大小等特性。其他剂量指标，如粒子数，体积，或表面积已被建议，但缺乏共识。关于纳米材料最适当剂量度量的讨论显然需要一种系统的、无偏见的方法来确定纳米材料最适当的剂量度量。在本研究中，作者提出了这样一种方法，并将其应用于银和二氧化硅纳米材料的体外和体内实验结果。所提出的方法被证明是一个方便的工具，系统地调查和解释纳米材料的剂量度量。提供了旨在研究剂量指标的研究设计建议。环境毒理化学2015;34：1015-1022。(c)2015年SETAC
Traditionally, administered mass is used to describe doses of conventional chemical substances in toxicity studies. For deriving toxic doses of nanomaterials, mass and chemical composition alone may not adequately describe the dose, because particles with the same chemical composition can have completely different toxic mass doses depending on properties such as particle size. Other dose metrics such as particle number, volume, or surface area have been suggested, but consensus is lacking. The discussion regarding the most adequate dose metric for nanomaterials clearly needs a systematic, unbiased approach to determine the most appropriate dose metric for nanomaterials. In the present study, the authors propose such an approach and apply it to results from in vitro and in vivo experiments with silver and silica nanomaterials. The proposed approach is shown to provide a convenient tool to systematically investigate and interpret dose metrics of nanomaterials. Recommendations for study designs aimed at investigating dose metrics are provided. Environ Toxicol Chem 2015;34:1015-1022. (c) 2015 SETAC