HISTOLOGIC FEATURES ASSOCIATED WITH LONG-TERM SURVIVAL IN BREAST-CANCER
HISTOLOGIC FEATURES ASSOCIATED WITH LONG-TERM SURVIVAL IN BREAST-CANCER
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DOI：
10.1016/s0046-8177(86)80085-5
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发表时间：
1986-10-01
期刊：
影响因子：
3.3
通讯作者：
FERGUSON, DJ
中科院分区：
文献类型：
--
作者：
DAWSON, PJ;KARRISON, T;FERGUSON, DJ
在浸润性乳腺导管癌 (NOS) 病例中发现了三种基本的细胞学变异。研究发现，与匹配的短命对照受试者相比，这些变异在乳房切除术后存活 25 年的患者中具有不同的分布。多变量分析表明，对这些细胞学变异的识别增强了肿瘤分级和血管侵袭的预后价值。此处指定为组织学 C 型的肿瘤患者（其他人称为侵袭性筛状癌）似乎比其他组织学亚型的患者具有更高的长期生存概率。由于他们约占 25 年幸存者的 20%，因此应将他们与其他类型浸润性导管癌 (NOS) 患者区分开来。
Three basic cytologic variants were identified among cases of infiltrating ductal carcinoma of the breast (NOS). These variants were found to have different distributions among patients surviving 25 years after mastectomy, compared with matched short-lived control subjects. Multivariate analyses indicated that recognition of these cytologic variants enhanced the prognostic value of tumor grade and blood vessel invasion. Patients with tumors designated here as histologic type C, which others have called invasive cribriform carcinoma, appear to have a higher probability of long-term survival than patients with other histologic subtypes. Since they account for approximately 20 per cent of 25-year survivors, they should be distinguished from patients with other types of infiltrating ductal carcinoma (NOS).