Identification of inhibitors of chromatin modifying enzymes using the yeast phenotypic screens.
Identification of inhibitors of chromatin modifying enzymes using the yeast phenotypic screens.
复制标题
使用酵母表型筛选鉴定染色质修饰酶抑制剂。
DOI：
10.1007/978-1-59745-540-4_8
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Bedalov,Antonio
中科院分区：
文献类型：
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作者：
Newcomb,Benjamin;Bedalov,Antonio
A multitude of enzymes that modify histones and remodel nucleosomes are required for the formation, maintenance, and propagation of the transcriptionally repressed chromatin state in eukaryotes. Robust phenotypic screens in yeastS. cerevisiaehave proved instrumental in identifying these activities and for providing mechanistic insights into epigenetic regulation. These phenotypic assays, amenable for high throughput small molecule screening, enable identification and characterization of inhibitors of chromatin modifying enzymes largely bypassing traditional biochemical approaches.
