Chatting histone modifications in mammals
Chatting histone modifications in mammals
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DOI：
10.1093/bfgp/elq024
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发表时间：
2010-12-01
影响因子：
4
通讯作者：
Schneider, Robert
中科院分区：
文献类型：
--
作者：
Izzo, Annalisa;Schneider, Robert
真核染色质可以是高度动态的，并且可以在开放转录活性构象和紧凑沉默构象之间连续交换。组蛋白的翻译后修饰在调节染色质状态中具有关键作用，从而影响所有依赖染色质的过程。甲基化是目前最具特征的组蛋白修饰之一，并且发生在精氨酸和赖氨酸残基上。组蛋白甲基化可以调节其他修饰（例如，G.乙酰化、磷酸化和泛素化），以定义精确的功能性染色质环境。在这篇综述中，我们集中在组蛋白甲基化和去甲基化，以及负责设置这些标志的酶。特别是，我们正在描述新的概念的相互依存的组蛋白修饰标记和讨论的分子机制，这种交叉谈判。
Eukaryotic chromatin can be highly dynamic and can continuously exchange between an open transcriptionally active conformation and a compacted silenced one. Post-translational modifications of histones have a pivotal role in regulating chromatin states, thus influencing all chromatin dependent processes. Methylation is currently one of the best characterized histone modification and occurs on arginine and lysine residues. Histone methylation can regulate other modifications (e. g. acetylation, phosphorylation and ubiquitination) in order to define a precise functional chromatin environment. In this review we focus on histone methylation and demethylation, as well as on the enzymes responsible for setting these marks. In particular we are describing novel concepts on the interdependence of histone modifications marks and discussing the molecular mechanisms governing this cross-talks.