Associations of protein intake in early childhood with body composition, height, and insulin-like growth factor I in mid-childhood and early adolescence
Associations of protein intake in early childhood with body composition, height, and insulin-like growth factor I in mid-childhood and early adolescence
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DOI：
10.1093/ajcn/nqy354
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发表时间：
2019-04-01
影响因子：
7.1
通讯作者：
Oken, Emily
中科院分区：
文献类型：
--
作者：
Switkowski, Karen M.;Jacques, Paul F.;Oken, Emily
背景：早期蛋白质摄入可能会影响后期的身体组成和身高增长，这可能是由胰岛素样生长因子I（IGF-I）介导的。在婴儿期，较高的蛋白质摄入量始终与较高的IGF-I浓度和更快的生长相关，但婴儿期后蛋白质摄入量与后期生长和IGF-I的相关性不太清楚。我们的目的是研究儿童早期蛋白质摄入量与（中位数3.2岁）与儿童中期（中位数7.7岁）和青春期早期（中位数13.0岁）的身高、IGF-I、肥胖和瘦体重指标以及这些结果随时间的变化进行比较。我们假设，早期儿童蛋白质摄入方案以后growth.Methods：我们研究了1165名儿童在波士顿地区的项目万岁队列。母亲使用食物频率问卷报告儿童的饮食。我们按儿童性别分层，并研究了儿童早期蛋白质摄入量与儿童中期和青少年早期BMI z评分、皮褶厚度、双能X线吸收法（DXA）脂肪量、DXA瘦体重、身高z评分和IGF-I浓度的相关性。我们调整了种族/民族，家庭社会人口统计学，父母和出生人体测量学，母乳喂养状态，体力活动，和快餐intake.Results的线性回归模型：平均蛋白质摄入量在幼儿期为58.3 g/d。儿童早期蛋白质摄入量与任何儿童中期结果无关。然而，在男孩中，幼儿期总蛋白质摄入量每增加10克与青少年早期体型的几个标志物相关，即BMI z评分（高0.12; 95%CI：0.01，0.23）、DXA瘦体重指数（高1.34%; 95%CI：-0.07%，2.78%）和循环IGF-I（高5.67%; 95%CI：0.30%，11.3%）。有没有协会与脂肪量和任何青少年的结果之间的女孩。结论：儿童早期蛋白质摄入量可能有助于编程瘦体重和IGF-I的青春期男孩的时间，但不是肥胖的发展。
Background: Early protein intake may program later body composition and height growth, perhaps mediated by insulin-like growth factor I (IGF-I). In infancy, higher protein intake is consistently associated with higher IGF-I concentrations and more rapid growth, but associations of protein intake after infancy with later growth and IGF-I are less clear.Objectives: Our objective was to examine associations of protein intake in early childhood (median 3.2 y) with height, IGF-I, and measures of adiposity and lean mass in mid-childhood (median 7.7 y) and early adolescence (median 13.0 y), and with changes in these outcomes over time. We hypothesized that early childhood protein intake programs later growth.Methods: We studied 1165 children in the Boston-area Project Viva cohort. Mothers reported children's diet using food-frequency questionnaires. We stratified by child sex and examined associations of early childhood protein intake with mid-childhood and early adolescent BMI z score, skinfold thicknesses, dual-energy X-ray absorptiometry (DXA) fat mass, DXA lean mass, height z score, and IGF-I concentration. We adjusted linear regression models for race/ethnicity, family sociodemographics, parental and birth anthropometrics, breastfeeding status, physical activity, and fast food intake.Results: Mean protein intake in early childhood was 58.3 g/d. There were no associations of protein intake in early childhood with any of the mid-childhood outcomes. Among boys, however, each 10-g increase in early childhood total protein intake was associated with several markers of early adolescent size, namely BMI z score (0.12 higher; 95% CI: 0.01, 0.23), DXA lean mass index (1.34% higher; 95% CI:-0.07%, 2.78%), and circulating IGF-I (5.67% higher; 95% CI: 0.30%, 11.3%). There were no associations with fat mass and no associations with any adolescent outcomes among girls.Conclusions: Early childhood protein intake may contribute to programming lean mass and IGF-I around the time of puberty in boys, but not to adiposity development.