ANALGESIC EFFECT OF IRVINGIA-GABONENSIS STEM BARK EXTRACT
ANALGESIC EFFECT OF IRVINGIA-GABONENSIS STEM BARK EXTRACT
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DOI：
10.1016/0378-8741(94)01199-a
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发表时间：
1995-02-01
影响因子：
5.4
通讯作者：
HUSSAINI, IM
中科院分区：
文献类型：
--
作者：
OKOLO, CO;JOHNSON, PB;HUSSAINI, IM
在热带非洲的大部分地区，加蓬树被用于治疗许多疾病。在西非，塞拉利昂的门德部落用树皮来缓解疼痛。为了建立这种植物作为治疗疼痛的传统用途的药理学原理，我们筛选了粉末茎皮的水和乙醇提取物的镇痛活性，并与标准镇痛药物进行了比较。水提取物和吗啡保护小鼠免受热引起的疼痛。相比之下，乙醇提取物和甲硝唑钠在这个测试中显示出非常低的镇痛活性。然而，使用尾部压力作为疼痛的来源，水和乙醇提取物、甲硝唑钠和吗啡可以保护小鼠免受疼痛刺激。吗啡和水提物在热痛试验中的镇痛作用强于非热痛试验。在两项试验中，水提取物和吗啡的镇痛作用均被非选择性阿片受体拮抗剂纳洛酮阻断，而乙醇提取物和甲硝唑钠的镇痛作用则未被相同剂量的阿片受体拮抗剂拮抗。本研究的数据表明，水提取物中的活性成分具有与麻醉性镇痛药相似的镇痛特性，而乙醇提取物可能含有与非麻醉性镇痛药相似的化合物。这些发现首次为民间使用加蓬藤止痛提供了药理学基础。
Irvingia gabonensis is used medicinally in most parts of tropical Africa for the treatment of a number of ailments. In West Africa the Mende tribe of Sierra Leone uses the stem bark to relieve pain. In order to establish a pharmacological rationale for the traditional use of this plant as a remedy for pain, the water and ethanol extracts of the powdered stem bark were screened for analgesic activity and compared with standard analgesic drugs. The water extract and morphine protected the mice from heat-induced pain. In contrast, the ethanol extract and metamizole sodium showed very low level of analgesic activity in this test. However, using tail pressure as a source of pain, the water and ethanol extracts, metamizole sodium and morphine offered protection to the mice against pain stimuli. Morphine and the water extract were more potent as analgesic agents in heat than non-heat pain test. The analgesic effects of the water extract and morphine were blocked by a non-selective opioid receptor antagonist, naloxone in both tests, whereas the analgesic effects of the ethanol extract and metamizole sodium were not antagonized by the same dose of the opioid antagonist. The data presented in this study suggest that the active principle(s) in the water extract has analgesic profile similar to that of the narcotic analgesic and the ethanol extract might contain compound(s) that behave like nonnarcotic analgesic agent. These findings provide for the first time the pharmacological basis for the folkloric use of Irvingia gabonensis in the relief of pain.