Treatment of adult-onset Still's disease: a review.
Treatment of adult-onset Still's disease: a review.
复制标题
DOI：
10.2147/tcrm.s64951
复制
发表时间：
2015
影响因子：
2.8
通讯作者：
Sève P
中科院分区：
文献类型：
--
作者：
Jamilloux Y;Gerfaud-Valentin M;Henry T;Sève P
成人起病斯蒂尔病(AOSD)是一种罕见的炎症性疾病，最近被归类为多基因自身炎症性疾病。以前基于病程的分类似乎已经相当过时了。事实上，越来越多的证据表明，根据细胞因子谱、临床表现和结果，AOSD可以分为两种不同的表型，即“全身型”和“关节型”。本综述的第一部分涉及目前可用于AOSD的治疗方法。然后根据疾病的特点，根据临床表现提出不同的治疗策略。要做到这一点，我们把重点放在疾病的两个子集上。最后，我们讨论了AOSD危及生命的并发症的处理，以及妊娠期的治疗选择。
Adult-onset Still’s disease (AOSD) is a rare inflammatory disorder that has been recently classified as a polygenic autoinflammatory disorder. The former classification, based on the disease course, seems to be quite dated. Indeed, there is accumulating evidence that AOSD can be divided into two distinct phenotypes based on cytokine profile, clinical presentation, and outcome, ie, a “systemic” pattern and an “articular” pattern. The first part of this review deals with the treatments that are currently available for AOSD. We then present the different strategies based on the characteristics of the disease according to clinical presentation. To do so, we focus on the two subsets of the disease. Finally, we discuss the management of life-threatening complications of AOSD, along with the therapeutic options during pregnancy.