Use of hand-held dynamometry in the evaluation of lower limb muscle strength in people with Huntington's disease
Use of hand-held dynamometry in the evaluation of lower limb muscle strength in people with Huntington's disease
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DOI：
10.1007/s00415-008-0964-x
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发表时间：
2008-10-01
影响因子：
6
通讯作者：
Rosser, Anne E.
中科院分区：
文献类型：
--
作者：
Busse, Monica E.;Hughes, Gareth;Rosser, Anne E.
在患有亨廷顿病（HD）的人中，已经报道了亚临床肌肉受累，包括肌病变化和骨骼肌线粒体功能障碍。使用手持式测力计评估肌肉力量。对20例HD患者和20例健康对照者的下肢6个肌群的等长肌力进行了测试，并对测试结果进行了信度和效度检验。HD患者采用统一的亨廷顿病评定量表（UHDRS）进行评估。使用组内相关系数（ICC）计算会话内可靠性。HD患者的UHDRS运动评分范围为28 ~ 80分。强度测试的可靠性极佳（ICC 0.86至0.98）。HD患者的平均力量大约是健康对照组的一半。UHDRS运动评分和力量评分显着相关（收敛），提供了进一步的指示强度testing.The手持测力计的有效性是一个可靠和有效的测量工具，以检测HD和匹配的对照组之间的力量差异。HD患者的下肢肌肉力量显著降低，这似乎在以前没有描述过。
Sub-clinical muscle involvement, including myopathic changes and mitochondrial dysfunction of skeletal muscle, has been reported in people with Huntington's disease (HD). Muscle strength was evaluated using a hand-held dynamometer. Reliability and validity in people with HD were determined.Isometric muscle strength of 6 lower limb muscle groups was measured in 20 people with HD and matched healthy controls. People with HD were evaluated with the Unified Huntington's Disease Rating Scales (UHDRS). Within session reliability using intra-class correlation coefficients (ICC) was calculated. Discriminant and convergent validity was also evaluated.UHDRS motor scores of people with HD ranged from 28 to 80. Reliability of strength testing was excellent (ICC 0.86 to 0.98). People with HD had on average about half the strength of healthy matched controls. UHDRS motor scores and strength scores were significantly correlated (convergent) providing a further indication of validity of strength testing.The hand-held dynamometer is a reliable and valid measurement tool to detect strength differences between people with HD and a matched control group. There is significant reduction in lower limb muscle strength in HD which does not appear to have been described previously.