Viruses as vectors of horizontal transfer of genetic material in eukaryotes
Viruses as vectors of horizontal transfer of genetic material in eukaryotes
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DOI：
10.1016/j.coviro.2017.06.005
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发表时间：
2017-08-01
影响因子：
5.9
通讯作者：
Cordaux, Richard
中科院分区：
文献类型：
--
作者：
Gilbert, Clement;Cordaux, Richard
遗传物质（主要是转座因子）的水平转移（HT）越来越被认为是形成真核生物基因组的重要因素。然而，我们对这些转让的机制和载体的了解仍然有限。有人提出，这种转移可能是由病毒促进的，因为它们通常将其基因组注入宿主细胞进行复制，并且它们可以在宿主之间水平传播。来自病毒群体和古病毒学的高通量测序的最新证据表明，病毒到宿主和宿主到病毒的基因流动在各种真核生物谱系中是常见的。我们认为，这些研究加强了假设的病毒作为主要载体的HT在真核生物。
Horizontal transfer (HT) of genetic material, mainly transposable elements, is increasingly recognized as an important factor shaping eukaryote genomes. Yet our understanding of the mechanisms and vectors underpinning these transfers is still limited. It has been proposed that such transfers may be facilitated by viruses, because they typically inject their genomes into host cells to replicate and they can be horizontally transmitted between their hosts. Recent evidence from high throughput sequencing of viral populations and paleovirology shows that both virus-to-host and host-to-virus gene flow can be common in a variety of eukaryote lineages. We argue that such studies reinforce the hypothesis of viruses as major vectors of HT in eukaryotes.