High Resolution of Racemic Mandelic Acid through a Method of Bubble Fractionation
High Resolution of Racemic Mandelic Acid through a Method of Bubble Fractionation
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DOI：
10.1002/cjoc.201090131
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发表时间：
2010-04
影响因子：
5.4
通讯作者：
F. Jiao;Lin Li;Xiaoqing Chen;Yue-hua Hu;Ling Yang
中科院分区：
文献类型：
--
作者：
F. Jiao;Lin Li;Xiaoqing Chen;Yue-hua Hu;Ling Yang
以2-羟丙基-β-环糊精（HP-β-CD）为手性捕收剂，采用鼓泡分级法拆分扁桃酸（MA）。考察了HP-β-CD浓度、回流平衡时间、气体流速、柱高度、缓冲液pH值等因素对分离性能的影响。根据鼓泡分馏过程与化学反应过程物理行为的相似性，引入了等效化学反应常数。用动力学方法对拆分过程进行了初步分析。结果表明，在最佳条件下，对映体过量可达60.7%。该过程可视为一级化学反应，其中等效速度常数kl=0.00376。该方法有助于实现器件的高分辨率和线性放大。
A method of bubble fractionation was developed for the resolution of racemic mandelic acid (MA), using 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) as chiral collector. The influences of concentration of HP-β-CD, reflux equilibriation time, gas flow rate, packing height of column and pH of buffer on resolution performance were investigated, respectively. According to the similar physical behavior of bubble fractionation and chemical reaction processes, the equivalent chemical reaction constant was introduced. The resolution process was preliminarily analyzed by means of kinetics. The results show that the enantiomeric excess of 60.7% can be obtained under the optimal conditions. The process could be regarded as a first order chemical reaction, where the equivalent speed constant was kl=0.00376. This method is helpful for realizing high resolution and linear amplification of device.