Future of Automated Insulin Delivery Systems
Future of Automated Insulin Delivery Systems
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DOI：
10.1089/dia.2017.0012
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发表时间：
2017-06-01
影响因子：
5.4
通讯作者：
Kovatchev, Boris
中科院分区：
文献类型：
--
作者：
Castle, Jessica R.;DeVries, J. Hans;Kovatchev, Boris
动态血糖监测（CGM）的进步带来了1型糖尿病管理的范式转变。这些进步已经实现了胰岛素输注的自动化，其中算法根据CGM值确定胰岛素输注速率。有多种自动胰岛素输送（AID）系统正在开发中。一个自动化基础胰岛素输注系统已经获得了食品和药物管理局的批准，更多的系统可能会跟进。随着AID领域的成熟，未来的系统可能会包含额外的激素和/或多种输入，如活动水平。所有的AID系统都受到CGM准确性的影响，未来的CGM设备必须显示出足够的准确性，才能安全地纳入AID。本文总结了近年来AID发展的成就，特别强调了CGM传感器的性能，并从输入输出特性、形状因子和适应性的角度讨论了AID系统的未来。
Advances in continuous glucose monitoring (CGM) have brought on a paradigm shift in the management of type 1 diabetes. These advances have enabled the automation of insulin delivery, where an algorithm determines the insulin delivery rate in response to the CGM values. There are multiple automated insulin delivery (AID) systems in development. A system that automates basal insulin delivery has already received Food and Drug Administration approval, andmore systems are likely to follow. As the field ofAID matures, future systemsmay incorporate additional hormones and/or multiple inputs, such as activity level. All AID systems are impacted byCGMaccuracy and futureCGMdevices must be shown to be sufficiently accurate to be safely incorporated into AID. In this article, we summarize recent achievements inAID development, with a special emphasis onCGMsensor performance, and discuss the future ofAID systems from the point of view of their input-output characteristics, form factor, and adaptability.