DISEASE EXPRESSION IN NONEXUDATIVE AGE-RELATED MACULAR DEGENERATION VARIES WITH CHOROIDAL THICKNESS
DISEASE EXPRESSION IN NONEXUDATIVE AGE-RELATED MACULAR DEGENERATION VARIES WITH CHOROIDAL THICKNESS
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DOI：
10.1097/iae.0000000000001689
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发表时间：
2018-04-01
影响因子：
3.3
通讯作者：
Spaide, Richard F.
中科院分区：
文献类型：
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作者：
Spaide, Richard F.
目的：目的：探讨非渗出性年龄相关性黄斑变性（AMD）患者中心凹下脉络膜厚度与临床表现的关系。将存在的细胞外沉积物、玻璃疣和视网膜下玻璃疣样沉积物（SDD，假性玻璃疣）沿着新识别的玻璃疣形式、厚玻璃疣进行分级，并与通过光学相干断层扫描测定的脉络膜厚度进行比较。结果：71例（94眼）患者，平均年龄78.1岁，平均年龄20岁。单纯玻璃疣45眼（47.9%），玻璃疣下存款伴或不伴玻璃疣38眼（40.4%）。厚玻璃疣直径大于125 ± 1.1 μ m，外轮廓不规则，后极部散在分布，孤立或成群发生11例（11.7%）。中心凹下脉络膜的平均厚度在软玻璃疣组中为227.9 μ m，在视网膜下玻璃疣样存款组中为167.3 μ m，在厚玻璃疣组中为419 μ m。结论：非渗出型AMD患者视网膜色素上皮细胞外沉积、视网膜下玻璃疣样沉积和玻璃疣分别位于视网膜色素上皮细胞两侧。一种新形式的玻璃疣表现可以与典型的软玻璃疣区分开来，并与较厚的脉络膜有关。非渗出性AMD的疾病表现似乎与脉络膜厚度有关。这些都有可能导致特定形式的晚期AMD。
Purpose: To investigate the relationship between subfoveal choroidal thickness and disease manifestation in a series of eyes with nonexudative age-related macular degeneration (AMD).Methods: Retrospective study of eyes with nonexudative AMD. The extracellular deposits present, drusen and subretinal drusenoid deposits (SDD, pseudodrusen) along with a newly recognized form of drusen, pachydrusen, were graded and compared with choroidal thickness as determined by optical coherence tomography. Demographic and imaging information was evaluated with descriptive statistics and generalized estimating equations.Results: There were 94 eyes of 71 patients, who had a mean age of 78.1 years. Soft drusen alone were found in 45 eyes (47.9%) and subretinal drusenoid deposit with or without drusen in 38 (40.4%). Pachydrusen, which were typically larger than 125 1.1,m, often had an irregular outer contour, showed a scattered distribution over the posterior pole and occurred in isolation or in groups of only a few drusen were found in 11 (11.7%). The mean subfoveal choroidal thickness in the soft drusen group was 227.9 mu m, in the subretinal drusenoid deposit group 167.3 mu m, and in the pachydrusen group 419 mu m. The differences between the groups were highly significant.Conclusion: Extracellular deposits, subretinal drusenoid deposits and drusen, which are on either side of the retinal pigment epithelium, respectively, are common in nonexudative AMD. A new form of drusen presentation could be differentiated from typical soft drusen and was associated with thicker choroids. Disease manifestation in nonexudative AMD seems to be associated with choroidal thickness. Each of these has potential to lead to specific forms of late AMD.