Cooperativity in macromolecular assembly
Cooperativity in macromolecular assembly
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DOI：
10.1038/nchembio.102
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发表时间：
2008-08-01
影响因子：
14.8
通讯作者：
Williamson, James R.
中科院分区：
文献类型：
--
作者：
Williamson, James R.
协同热力学原理用于驱动大分子机器组装过程中特定大分子复合物的形成。了解协同性可以深入了解控制多组分复合体组装和分解的机制。我们对组装机制的理解远远落后于对这些复合物的结构和功能的理解。解决所有细胞功能所需的分子间相互作用的热力学和动力学仍然是一个重大挑战。
The thermodynamic principle of cooperativity is used to drive the formation of specific macromolecular complexes during the assembly of a macromolecular machine. Understanding cooperativity provides insight into the mechanisms that govern assembly and disassembly of multicomponent complexes. Our understanding of assembly mechanisms is lagging considerably behind our understanding of the structure and function of these complexes. A significant challenge remains in tackling the thermodynamics and kinetics of the intermolecular interactions required for all cellular functions.