The formation of hydroxyapatite‐gelatin composites at 38°C
The formation of hydroxyapatite‐gelatin composites at 38°C
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38°C 羟基磷灰石-明胶复合材料的形成
DOI：
10.1002/jbm.820280105
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
P. Brown
中科院分区：
文献类型：
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作者：
K. Tenhuisen;P. Brown
由缺钙羟基磷灰石（CA/P = 1.5）和明胶组成的复合材料在38°C下约4小时形成。所用的固体反应物是CaHPO 4和Ca 4（PO 4）2 O，液体反应物是明胶溶液。形成羟基磷灰石的反应分几步进行。根据放热的测量，存在反应速率低的初始阶段。这之后是一段时间的恒定反应，直到反应完成。pH变化的分析表明，羟基磷灰石形成发生在接近8.2的稳态pH。晶相演化分析表明，在完全反应之前，Ca 4（PO 4）2 O被消耗，导致羟基磷灰石（CA/P > 1.5）和CaHPO 4的相组合。随着CaHPO 4的消耗，进一步的反应导致羟基磷灰石的组成调整。在微观结构上，形成的复合材料由嵌入明胶网络中的羟基磷灰石簇组成。明胶的存在不影响形成的羟基磷灰石的形态，也不阻碍其形成速率。John Wiley & Sons，Inc.
Composites comprised of calcium deficient hydroxyapatite (CA/P = 1.5) and gelatin form in about 4 h at 38°C. The solid reactants used are CaHPO4 and Ca4(PO4)2O and the liquid reactant is gelatin solution. The reaction forming hydroxyapatite occurs in several steps. Based on the measurement of heat liberation, there is an initial period where the reaction rate is low. This is followed by a period of constant reaction until the reaction is complete. Analysis of the variation in pH shows that hydroxyapatite formation occurs at a steady state pH near 8.2. Analyses of the evolution of crystalline phases indicates that Ca4(PO4)2O is consumed prior to complete reaction resulting in a phase assemblage of hydroxyapatite (CA/P > 1.5) and CaHPO4. Further reaction results in compositional adjustments in hydroxyapatite as CaHPO4 is consumed. Microstructurally, the composites which form consist of clusters of hydroxyapatite embedded in a gelatin network. The presence of gelatin does not influence the morphology of the hydroxyapatite which forms nor does it retard its rate of formation. © 1994 John Wiley & Sons, Inc.