High mutability in male hybrids of Drosophila melanogaster.
High mutability in male hybrids of Drosophila melanogaster.
复制标题
黑腹果蝇雄性杂交种的高突变性。
DOI：
10.1093/genetics/96.2.479
复制
发表时间：
1980
期刊：
影响因子：
3.3
通讯作者：
Raymond,JD
中科院分区：
文献类型：
--
作者：
Simmons,MJ;Johnson,NA;Fahey,TM;Nellett,SM;Raymond,JD
性连锁致死突变的频率产生的杂交雄性后代从各种杂交和非杂交对照进行了测定。这些杂种是通过将杂种不育的P-M系统的代表性菌株在所有可能的组合中杂交产生的。P系雄性× M系雌性杂交产生的雄性的突变率比P系非杂交雄性的突变率高15倍。基因相同的男性从相互交叉的突变率的3至4倍的非杂交。对于涉及Q菌株的杂交，在Q雄性与M雌性交配产生的雄性中检测到突变率显著增加。在相互交配的遗传相同雄性中未观察到增加。PandQ株之间的杂交产生的雄性杂交种的突变率与非杂交种的突变率没有不同。P雄性× M雌性杂交的杂种中发生的许多致死事件似乎是不稳定的; Q雄性× M雌性杂交的杂种中出现的少数致死事件是不稳定的。PandQ株之间的关系进行了讨论，相对于一个模型的突变诱导在基因缺陷的杂交。
The frequencies of sex-linked lethal mutations arising in hybrid male offspring from various crosses and in nonhybrid controls were determined. The hybrids were produced by crossing representative strains of theP-Msystem of hybrid dysgenesis in all possible combinations. Males from the cross ofPmales ×Mfemales had a mutation rate about 15 times higher than that of nonhybrid males from thePstrain. Genetically identical males from the reciprocal cross had a mutation rate 3 to 4 times that of the nonhybrids. For crosses involving aQstrain, a significant increase in the mutation rate was detected in males produced by matings ofQmales withMfemales. No increase was observed in genetically identical males from the reciprocal mating. Crosses betweenPandQstrains gave male hybrids with mutation rates not different from those of nonhybrids. Many of the lethals that occurred in hybrids from the cross ofPmales ×Mfemales appeared to be unstable; fewer lethals that arose in hybrids from the cross ofQmales ×Mfemales were unstable. The relationship betweenPandQstrains is discussed with respect to a model of mutation induction in dysgenic hybrids.