New Understanding on the Pathophysiology and Treatment of Constipation in Parkinson's Disease.
New Understanding on the Pathophysiology and Treatment of Constipation in Parkinson's Disease.
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帕金森病便秘的病理生理学和治疗新认识
DOI：
10.3389/fnagi.2022.917499
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发表时间：
2022
影响因子：
4.8
通讯作者：
中科院分区：
文献类型：
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作者：
便秘是帕金森病 (PD) 最常见的前驱非运动症状之一，通常比运动症状出现早几年。先前的研究表明，随着疾病的进展，便秘的发生率会增加。然而，这种病理性疾病的机制尚不清楚。此外，慢性便秘会导致胃排空缓慢，因此可能导致帕金森病药物（包括左旋多巴和多巴胺激动剂）的吸收延迟。因此，有必要了解PD期间便秘的病理生理因素，并采取精准有效的治疗策略。在这篇综述中，我们总结了帕金森病引起的便秘的分子机制，并更新了帕金森病相关便秘的治疗进展。
Constipation, one of the most common prodromal non-motor symptoms of Parkinson’s disease (PD), usually occurs several years earlier than the onset of motor symptoms. Previous studies have shown that constipation occurrence increases as the disease progresses. However, the mechanism underlying this pathologic disorder is not clear yet. Moreover, chronic constipation causes slowness in gastric emptying and, therefore, may lead to a delay in the absorption of medications for PD, including levodopa and dopamine agonists. Accordingly, it is necessary to understand how the pathophysiological factors contribute to constipation during PD as well as pursue precise and effective treatment strategies. In this review, we encapsulate the molecular mechanism of constipation underlying PD and update the progress in the treatments of PD-associated constipation.