Measuring nicotine intake in population surveys: Comparability of saliva cotinine and plasma cotinine estimates
Measuring nicotine intake in population surveys: Comparability of saliva cotinine and plasma cotinine estimates
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DOI：
10.1080/1462220031000094213
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发表时间：
2003-06-01
影响因子：
4.7
通讯作者：
Bryant, A
中科院分区：
文献类型：
--
作者：
Jarvis, MJ;Primatesta, P;Bryant, A
吸烟行为调查中报告了血浆和唾液可替宁水平，了解这两种测量值的对应程度是很有意义的。从 1998 年英国健康调查中 605 名受访者的样本中采集血浆和唾液样本，并通过经过充分验证的气相色谱方法测定可替宁。血浆和唾液可替宁浓度高度相关 (r=.99)。平均而言，唾液中的浓度比血浆中的浓度高 25%，并且该比率既适用于被动吸烟导致的低水平，也适用于主动吸烟值的范围。年轻人的这一比例略低于老年人，并且体重指数也有显着差异，但没有性别差异。一致性极限的计算揭示了与给定唾液可替宁相对应的预测血浆值存在很大的不确定性，反之亦然。对于受试者之间的比较，可以可靠地估计与平均唾液可替宁水平相对应的平均血浆可替宁水平，但在个体水平上，仍然存在相当大的预测不确定性。
Both plasma and saliva cotinine levels have been reported in surveys of smoking behavior, and it is of interest to know how closely these two measures correspond. Plasma and saliva specimens were gathered from a sample of 605 respondents in the 1998 Health Survey for England and assayed for cotinine by a well-proven gas chromatographic method. Plasma and saliva cotinine concentrations were highly correlated (r=.99). On average, concentrations in saliva were 25% higher than in plasma, and this ratio applied both at the low levels attributable to passive smoking and across the range of active smoking values. The ratio was somewhat lower in younger people than in older people and also varied significantly by body mass index but did not differ by gender. Calculation of the limits of agreement revealed substantial uncertainty in the predicted plasma value corresponding to a given saliva cotinine, and vice versa. For comparisons across subjects, the mean plasma cotinine level corresponding to a mean saliva cotinine level can be estimated with confidence, but at the level of the individual, considerable predictive uncertainty remains.