Rearrangement of Atrial Bundle Architecture and Consequent Changes in Anisotropy of Conduction Constitute the 3-Dimensional Substrate for Atrial Fibrillation
Rearrangement of Atrial Bundle Architecture and Consequent Changes in Anisotropy of Conduction Constitute the 3-Dimensional Substrate for Atrial Fibrillation
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DOI：
10.1161/circep.113.000050
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发表时间：
2013-10-01
影响因子：
8.4
通讯作者：
Schotten, Ulrich
中科院分区：
文献类型：
--
作者：
Maesen, Bart;Zeemering, Stef;Schotten, Ulrich
背景传导各向异性有助于房颤的再入，因此是房颤稳定性的关键决定因素。关于房颤对房束构筑的影响以及由此引起的房颤传导和维持各向异性的变化，目前还知之甚少。方法和结果在山羊急性房颤(n=6)和持续性房颤(n=5)的左心房进行直接接触标测。分析了各向异性导电性的程度和方向。标测的组织区域由高分辨率MRI成像，以识别心内膜和心外膜束方向。定量分析心内膜和心外膜束方向以及束方向和各向异性传导之间的相关性。在持续性房颤中，心外膜束更垂直于心内膜束，而在急性房颤中(%角度
Background Anisotropy of conduction facilitates re-entry and is, therefore, a key determinant of the stability of atrial fibrillation (AF). Little is known about the effect of AF on atrial bundle architecture and consequent changes in anisotropy of conduction and maintenance of AF.Methods and Results Direct contact mapping was performed in left atria of goats with acute AF (n=6) or persistent AF (n=5). The degree and direction of anisotropic conduction were analyzed. Mapped tissue regions were imaged by high-resolution MRI for identification of endocardial and epicardial bundle directions. Correlation between endocardial and epicardial bundle directions and between bundle directions and anisotropic conduction was quantified. In persistent AF, epicardial bundles were oriented more perpendicularly to endocardial bundles than in acute AF (% angles