TIME AND DOSE DEPENDENCY OF BONE-SARCOMAS IN PATIENTS INJECTED WITH RADIUM-224
TIME AND DOSE DEPENDENCY OF BONE-SARCOMAS IN PATIENTS INJECTED WITH RADIUM-224
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DOI：
10.1007/bf01214600
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发表时间：
1988-01-01
影响因子：
1.7
通讯作者：
SPIESS, H
中科院分区：
文献类型：
--
作者：
CHMELEVSKY, D;KELLERER, AM;SPIESS, H
900例德国患者接受高剂量镭-224治疗的骨肉瘤的发病率的时间过程和剂量依赖性进行了分析的比例风险模型与时间的对数正态依赖性肿瘤和线性二次剂量关系。推导出的剂量依赖性同意与以前的非参数比例风险模型方面的分析，并证实了时间分布已被用于美国国立卫生研究院的放射流行病学表。然而，线性-二次剂量-反应模型给出的低剂量风险估计值略低于线性假设下获得的风险估计值的一半。
The time course and dose dependency of the incidence of bone-sarcomas among 900 German patients treated with high doses of radium-224 is analysed in terms of a proportional hazards model with a log-normal dependency of time to tumor and a linear-quadratic dose relation. The deduced dose dependency agrees well with a previous analysis in terms of a non-parametric proportional hazards model, and confirms the temporal distribution which has been used in the Radioepidemiological Tables of NIH. However, the linear-quadratic dose-response model gives a risk estimate for low doses which is somewhat less than half that obtained under the assumption of linearity.