A prospective longitudinal study of neuropsychological and psychosocial factors in asymptomatic individuals at risk for HTLV-III/LAV infection in a methadone program: preliminary findings.
A prospective longitudinal study of neuropsychological and psychosocial factors in asymptomatic individuals at risk for HTLV-III/LAV infection in a methadone program: preliminary findings.
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对美沙酮计划中有 HTLV-III/LAV 感染风险的无症状个体的神经心理和心理社会因素的前瞻性纵向研究：初步结果。
DOI：
10.3109/00207458709043321
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Gerald Friedland
中科院分区：
文献类型：
--
作者：
Charles H. Silberstein;F. McKegney;M. O’Dowd;Peter A. Selwyn;Ellie Schoenbaum;Ernest Drucker;Cheryl Feiner;Charles P. Cox;Gerald Friedland
为了检验HTLV-III/LAV感染过程早期可能存在认知障碍的假设，对没有明显艾滋病相关疾病症状的静脉吸毒者（IDVA）进行了标准神经心理学和心理社会测量。本研究是在该高危人群中进行HTLV-III/LAV感染自然史前瞻性纵向研究的基线。在最初评价的211例受试者中，70例（33%）为HTLV-III/LAV血清阳性，141例（67%）为血清阴性。在基线时，通过单变量分析，血清阳性IVDAs在8项测量中的4项上比血清阴性IVDAs显著受损（p <0.05）：手指敲击-优势，手，手指向前跨度，轨迹制作A和WAIS相似性。然而，通过多变量分析，血清阳性显着受损的WAIS相似性和韦氏联想学习测试。多种因素，如药物使用和心理压力可能会影响测试性能。然而，这些初步结果表明，血清阳性IVDAs可能显示出受损的神经心理功能的证据，即使在没有艾滋病相关的症状，并与HTLV-III/LAV的早期嗜神经性的假设是一致的。
To test the hypothesis that cognitive impairment may be present early in the course of HTLV-III/LAV infection, intravenous drug abusers (IDVAs) without overt symptoms of AIDS related illness were tested with standard neuropsychological and psychosocial measures. This study is the baseline for a prospective longitudinal study of the natural history of HTLV-III/LAV infection in this high risk population. Of 211 subjects initially evaluated, 70 (33%) were HTLV-III/LAV seropositive and 141 (67%) were seronegative. At the baseline, by univariate analysis, the seropositive IVDAs were significantly (p less than .05) more impaired than seronegatives on 4 of 8 measures: Finger Tapping--dominant, hand, Digit Span Forward, Trail making A and WAIS-Similarities. However, by multivariate analysis the seropositives were significantly more impaired only on the WAIS-Similarities and Wechsler--Associative Learning tests. Multiple factors such as drug use and psychological stress may have influenced test performance. These preliminary results, however, suggest that seropositive IVDAs may show evidence of impaired neuropsychological function even in the absence of AIDS related symptoms and are consistent with the hypothesis of the early neurotropism of HTLV-III/LAV.