Microbiome Structural and Functional Interactions across Host Dietary Niche Space
Microbiome Structural and Functional Interactions across Host Dietary Niche Space
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DOI：
10.1093/icb/icx011
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发表时间：
2017-10-01
影响因子：
2.6
通讯作者：
Kingston, Tigga
中科院分区：
文献类型：
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作者：
Phillips, Caleb D.;Hanson, John;Kingston, Tigga
寄主相关微生物群是寄主健康不可或缺的组成部分，但寄主之间和寄主内部的微生物群落结构各不相同。协调社区变异性与宿主对社区功能的明显依赖，并表征不同利基之间的功能差异如何进行，仍然是具有挑战性的。在这里，通过对三种食虫蝙蝠的肠道微生物和饮食的研究，我们描述了群落结构是如何由群落成员的预测功能特性来塑造的。我们发现，虽然宿主饮食和微生物群落组成之间没有显著的相关性，但宿主饮食和元基因组功能之间存在显著的相关性，这表明饮食直接选择了元基因组功能而不是群落。我们使用一个新的推理框架来说明群落结构和功能变异之间的不一致性是如何从功能等价性派生出来的，并受到微生物谱系中共享和派生的基因集的连续体的影响。我们的发现有助于阐明元基因组群落结构-功能关系如何有助于群落组装中的确定性过程，并描述生态相似宿主之间元基因组差异的基础。
Host-associated microbiomes are integral components of host health, but microbiome community structure varies among and within hosts. Reconciling community variability with the apparent dependence of hosts on community function, and characterizing how functional divergence proceeds across niches, remains challenging. Here, through the study of gut microbiomes and diets of three insectivorous bat species we characterize how community structure is shaped by predicted functional properties of community members. We found that while host diet and microbiome community composition do not significantly relate to each other, host diet and metagenome function do, suggesting that diet directly selects metagenomic functions rather than communities. We use a novel inference framework to show how the discordance between community structure and functional variation derives from functional equivalence and is influenced by the continuum of shared and derived gene sets across microbial lineages. Our findings help clarify how metagenome community structure-function relationships contribute to deterministic processes in community assembly, and describe the basis for metagenomic differences across ecologically similar hosts.