Improved survival of patients with hypermutation in uterine serous carcinoma.
Improved survival of patients with hypermutation in uterine serous carcinoma.
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DOI：
10.1016/j.gore.2015.01.005
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发表时间：
2015-04
影响因子：
1.2
通讯作者：
Lifton, Richard
中科院分区：
文献类型：
--
作者：
Santin, Alessandro D;Bellone, Stefania;Centritto, Floriana;Schlessinger, Joseph;Lifton, Richard
子宫浆液性癌（USC）是子宫内膜癌的一种侵袭性亚型。
在一部分子宫浆液性癌中检测到DNA聚合酶ε基因（POLE）突变，且该突变呈现出一种强突变表型。
被诊断出具有POLE突变的子宫浆液性癌患者预后明显更好。
Uterine serous carcinoma (USC) is an aggressive subtype of endometrial cancer. Mutations in DNA polymerase ε gene (POLE) are detected in a subset of USC and confer a strong mutator phenotype. USC patients diagnosed with POLE mutations experience a significantly better prognosis.