Helicobacter pylori infection in two areas in Japan with different risks for gastric cancer
Helicobacter pylori infection in two areas in Japan with different risks for gastric cancer
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DOI：
10.1111/j.1365-2036.2004.01976.x
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发表时间：
2004-07-01
影响因子：
7.6
通讯作者：
Shinomura, J
中科院分区：
文献类型：
--
作者：
Nobuta, A;Asaka, M;Shinomura, J
背景资料：我们评估了幽门螺杆菌与胃癌相关的各种因素之间的关系，在日本的两个地区，不同的风险，由于胃癌的死亡率。方法：共250血清从新泻和209从冲绳被使用。H. pylori抗体和CagA抗体用抗原特异性ELISA法测定。结果：H。新泻和冲绳人群的pylori感染率分别为50%和42%，CagA感染率分别为41%和26%，差异有统计学意义（OR = 1.98，95%CI：1.33-2.95，P < 0.01）。新泻的血清胃泌素水平显著低于冲绳。pylori阴性者（P < 0.01）。血清胃蛋白酶原I/II比值在新泻显著低于冲绳。pylori阳性者之间差异有显著性（P < 0.01），而H.幽门阴性的人。H.幽门螺杆菌感染者血清胃蛋白酶原I/II比值在新泻显著低于冲绳CagA阳性组与阴性组比较差异有显著性（P < 0.01），而CagA阳性组与阴性组比较差异无显著性（P> 0.05）。这些结果表明，新泻和冲绳之间胃癌死亡率的差异主要与cagA流行率的地区差异有关。阳性菌株而不是H. pylori本身
Background: We evaluated the relationship between Helicobacter pylori and various factors associated with gastric cancer in two areas in Japan with different risks for mortality due to gastric cancer.Methods: A total of 250 sera from Niigata and 209 from Okinawa were used. H. pylori antibody and CagA antibody were measured by antigen-specific ELISAs. Serum gastrin and pepsinogen levels were determined by RIA.Results: Although there was no significant difference in H. pylori prevalence among the persons in Niigata (50%) and Okinawa (42%), CagA prevalence in these populations was significantly different, at 41% and 26%, respectively (OR = 1.98, 95%CI: 1.33-2.95, P < 0.01). Serum gastrin levels in Niigata were significantly lower than those in Okinawa in H. pylori-negative persons (P < 0.01). The serum pepsinogen I/II ratio in Niigata was significantly lower than that in Okinawa in H. pylori positive persons (P < 0.01), whereas there was no significant difference in H. pylori-negative persons. Among those positive for H. pylori, serum pepsinogen I/II ratio in Niigata was significantly lower than that in Okinawa in CagA-negative persons (P < 0.01), whereas no significant difference was observed in CagA-positive persons.Conclusions: These results suggest that the difference in the mortality ratio of gastric cancer between Niigata and Okinawa is mainly associated with the difference between areas in the prevalence of cagA-positive strains rather than that of H. pylori itself.