Inhibition of growth of Mycobacterium avium in murine and human mononuclear phagocytes by migration inhibitory factor.
Inhibition of growth of Mycobacterium avium in murine and human mononuclear phagocytes by migration inhibitory factor.
复制标题
通过迁移抑制因子抑制鼠和人单核吞噬细胞中鸟分枝杆菌的生长。
DOI：
10.1128/iai.61.1.338-342.1993
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发表时间：
1993
影响因子：
3.1
通讯作者：
Weiser,WY
中科院分区：
文献类型：
--
作者：
Orme,IM;Furney,SK;Skinner,PS;Roberts,AD;Brennan,PJ;Russell,DG;Shiratsuchi,H;Ellner,JJ;Weiser,WY
Infections caused by Mycobacterium avium, the most common form of diseminated bacterial disease in AIDS patients, are difficult to treat because of their resistance to many antimycobacterial drugs. The results of the present study show that recombinant migration inhibitory factor, a 12-kDa molecule recently isolated by COS-1 cell expression screening of cDNA from a human T-cell hybridoma, has potent inhibitory activity on the growth of a panel of clinical isolates of M. avium within both bone-marrow-derived murine macrophages and cultured human blood monocytes. These cells cultured in recombinant migration inhibitory factor exhibit various signs of activation, including cell division, morphological changes such as evidence of substantial phagolysosomal fusion, and enhanced secretion of tumor necrosis factor.
