1-trichloromethyl-1,2,3,4-tetrahydro-β-carboline (TaClo) induces apoptosis in human neuroblastoma cell lines
1-trichloromethyl-1,2,3,4-tetrahydro-β-carboline (TaClo) induces apoptosis in human neuroblastoma cell lines
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DOI：
10.1196/annals.1299.053
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发表时间：
2003-01-01
期刊：
影响因子：
--
通讯作者：
Fiebich, BL
中科院分区：
文献类型：
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作者：
Akundi, RS;Hüll, M;Fiebich, BL
众所周知，以前广受欢迎的催眠剂水合氯醛在体内会自发与色胺缩合，产生高度无极性的1-trichloromethyl-1，2，3，4-tetrahydro-beta-carboline(Taclo)衍生物。早期的研究已经揭示了这种分子在体内的相对渗透性，以及它在大鼠身上引发帕金森样症状的能力。在这项研究中，我们报道了Taclo是一种高度细胞毒性的药物，它能导致人神经母细胞瘤细胞的凋亡，涉及caspase-3的激活。
The former popular hypnotic chloral hydrate has been known to spontaneously condense with tryptamine in the body to give rise to a highly unpolar 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) derivative. Earlier studies have revealed the relative permeability of the molecule through the body, and its ability to induce Parkinson-like symptoms in rats. In this study, we report that TaClo is a highly cytotoxic agent that leads to apoptosis in human neuroblastoma cells involving caspase-3 activation.