NEUROLOGIC SYMPTOMS ASSOCIATED WITH PARENTERAL ACYCLOVIR TREATMENT AFTER MARROW TRANSPLANTATION
NEUROLOGIC SYMPTOMS ASSOCIATED WITH PARENTERAL ACYCLOVIR TREATMENT AFTER MARROW TRANSPLANTATION
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DOI：
10.7326/0003-4819-98-6-921
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发表时间：
1983-01-01
影响因子：
39.2
通讯作者：
MEYERS, JD
中科院分区：
文献类型：
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作者：
WADE, JC;MEYERS, JD
接受不同剂量阿昔洛韦[一种抗病毒药物]治疗疱疹病毒感染的6名骨髓移植受者在治疗期间出现神经症状。其中三人正在接受人类阿尔法相伴。干扰素，所有6人都接受过鞘内注射甲氨蝶呤。开始治疗后平均8天(2-18天)出现症状，包括5例嗜睡或躁动，5例震颤，1例定向障碍或一过性偏瘫。唯一一致的实验室发现是异常的脑电波。5例患者脑脊液髓鞘碱性蛋白水平升高。阿昔洛韦停药后症状改善或缓解的平均时间为13天(4-15天)。大范围使用阿昔洛韦可能与骨髓移植后患者可逆的神经症状有关。既往预防中枢神经系统白血病、疱疹病毒感染、骨髓移植或同时使用干扰素的作用尚不清楚。
Six marrow transplant recipients receiving acyclovir [an antiviral agent] at various dosages for herpesvirus infections developed neurologic symptoms during treatment. Three were receiving concomitant human .alpha. interferon, and all 6 had received previous intrathecal methotrexate. Symptoms developed a median of 8 days (range, 2-18 days) after initiation of therapy and consisted of lethargy or agitation in 5 patients, tremor in 5 and disorientation or transient hemiparesthesias in 1 patient each. The only consistent laboratory finding was an abnormal EEG. Five patients had an increased myelin basic protein level in CSF. Improvement or resolution of symptoms occurred a median of 13 days (range, 4-15 days) after cessation of acyclovir therapy. Acyclovir used at a wide range of dosages may be associated with reversible neurologic symptoms in patients after marrow transplantation. The contribution of previous prophylaxis for CNS leukemia, herpesvirus infections, marrow transplanation or the concomitant use of interferon, is unknown.