Dihydroceramide-desaturase-1-mediated caspase 9 activation through ceramide plays a pivotal role in palmitic acid-induced HepG2 cell apoptosis
Dihydroceramide-desaturase-1-mediated caspase 9 activation through ceramide plays a pivotal role in palmitic acid-induced HepG2 cell apoptosis
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二氢神经酰胺去饱和酶 1 通过神经酰胺介导的 caspase 9 激活在棕榈酸诱导的 HepG2 细胞凋亡中发挥关键作用
DOI：
10.1007/s10495-016-1267-9
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发表时间：
2016
期刊：
影响因子：
7.2
通讯作者：
Junfei Jin
中科院分区：
文献类型：
--
作者：
Qun Zhu;Jianjun Yang;Rongping Zhu;Xin Jiang;Wanlian Li;Songqing He;Junfei Jin
在这项研究中，结果表明，PA诱导的HepG 2细胞生长的抑制以时间和浓度依赖性的方式发生，caspase 9的激活是PA诱导的HepG 2细胞凋亡所必需的，二氢神经酰胺去饱和酶1（DES 1）在PA介导的caspase 9和caspase 3激活中起关键作用，棕榈油酸（POA），一种ω-7单不饱和脂肪酸，通过DES 1 → Ceramide → Caspase 9 → Caspase 3信号通路逆转PA诱导的细胞凋亡。
In this study, results showed that the inhibition of PA-induced HepG2 cell growth takes place in a time- and concentration-dependent manner, that activation of caspase 9 is necessary for PA-induced HepG2 cell apoptosis, that dihydroceramide desaturase 1 (DES1) plays a key role in PA-mediated caspase 9 and caspase 3 activation, and that palmitoleic acid (POA), an omega-7 monounsaturated fatty acid, reverses PA-induced apoptosis through DES1 → Ceramide → Caspase 9 → Caspase 3 signaling.