Prevalence of Chlamydophila psittaci infections in a human population in contact with domestic and companion birds
Prevalence of Chlamydophila psittaci infections in a human population in contact with domestic and companion birds
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DOI：
10.1099/jmm.0.011379-0
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发表时间：
2009-09-01
影响因子：
3
通讯作者：
Vanrompay, Daisy
中科院分区：
文献类型：
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作者：
Harkinezhad, Taher;Verminnen, Kristel;Vanrompay, Daisy
人类的鹦鹉热嗜衣原体感染被低估了。我们调查了C.在比利时540只鹦鹉热中。数据来自一项对35-55岁的明显健康的社区居民受试者进行的人口调查（n=2524）。采集咽拭子和血液。个人完成了一份关于专业和非专业活动、吸烟习惯、病史和与不同鸟类接触频率的问卷。拭子用C.鹦鹉热特异性PCR和嗜肺炎衣原体特异性PCR。用重组C.鹦鹉热主要外膜蛋白为基础的ELISA，一个C。基于鹦鹉热全生物体的ELISA（Serion）和微量免疫荧光测试（Focus Diagnostics）。结果证实了我们对比利时鹦鹉热低估的怀疑。鹦鹉形目和赛鸽是主要传染源。饮酒过量（定义为每日平均饮酒量>2个单位）的妇女比男子更容易感染。我们分析了血清阳性和/或PCR阳性对炎症的影响（白色血细胞计数、高敏C反应蛋白、纤维蛋白原）。一般而言，血清阳性显示炎症变量水平略高的趋势（均不显著），而PCR阳性显示无影响或甚至炎症水平较低的趋势。
Chlamydophila psittaci infections in humans are underestimated. We investigated the occurrence of C. psittaci in a Belgian population of 540 individuals. Data were from a population survey (n=2524) of apparently healthy community-dwelling subjects aged 35-55 years. Pharyngeal swabs and blood were taken. Individuals completed a questionnaire on professional and nonprofessional activities, smoking habits, medical history and contact frequency with different bird species. Swabs were analysed by a C. psittaci-specific and a Chlamydophila pneumoniae-specific PCR. Sera were tested by a recombinant C. psittaci major outer-membrane protein-based ELISA, a C. psittaci whole organism-based ELISA (Serion) and a micro-immunofluorescence test (Focus Diagnostics). Results confirmed our suspicion about the underestimation of psittacosis in Belgium. Psittaciformes and racing pigeons were the main infection source. Women with excessive alcohol intake defined as a mean intake of >2 units daily were more frequently infected than men. We analysed the effect of seropositivity and/or PCR positivity on inflammation (white blood cell count, high-sensitivity C-reactive protein, fibrinogen). In general, seropositivity showed a trend to slightly higher levels of inflammatory variables (all nonsignificant), whilst PCR positivity showed a trend to no effect or even lower inflammatory levels.