Macroscopic complete resection: the goal of primary surgery in multimodality therapy for pleural mesothelioma.
Macroscopic complete resection: the goal of primary surgery in multimodality therapy for pleural mesothelioma.
复制标题
宏观完全切除：胸膜间皮瘤多模式治疗中初次手术的目标。
DOI：
10.1016/s1556-0864(15)31536-7
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
D. Sugarbaker
中科院分区：
文献类型：
--
作者：
D. Sugarbaker
Multimodality therapy for solid tumors is based on a strategy of cytoreduction of the primary tumor by surgery, radiation, or ablative therapy. Adjuvant therapy, usually involving chemotherapy, radiotherapy, or biologics, is then used with the goal of completing the cytoreductive process by eliminating micrometastatic disease remaining at the local margins and/or disseminated systemically via hematogenous and lymphangitic routes. The selection of modalities for a given malignancy is based on the observed locoregional and/or systemic patterns of recurrence. Therapeutic impact is dependent on the initial tumor burden and disease stage at the time of therapy and the availability of effective primary and adjuvant modalities.For malignant pleural mesothelioma (MPM), available local and systemic modalities have been inadequate to effect a cure, and the goal of therapy is thus to improve the quality and duration of life. In this regard, multimodality therapy based on surgical cytoreduction has resulted in life extension for selected patients relative to single-modality or palliative treatments.
