MicroRNA miR-146a-5p inhibits the inflammatory response and injury of airway epithelial cells via targeting TNF receptor-associated factor 6
MicroRNA miR-146a-5p inhibits the inflammatory response and injury of airway epithelial cells via targeting TNF receptor-associated factor 6
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DOI：
10.1080/21655979.2021.1927545
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发表时间：
2021
期刊：
影响因子：
4.9
通讯作者：
王晶
中科院分区：
文献类型：
--
作者：
闫芳;迪丽努尔·乌甫尔;丁剑冰;王晶
Bronchial asthma is a common respiratory disease, which is characterized by airway inflammation, .remodeling and hyperresponsiveness. MicroRNAs (miRNAs), as reported, are implicated in the .pathogenesis of many diseases, but how miRNAs-146a-5p (miR-146a-5p) works in asthma remains .inconclusive. In this work, we proved that miR-146a-5p expression was inhibited in asthma .patients’ plasma and platelet activating factor (PAF)-induced human small airway epithelial cells .(HSAECs). MiR-146a-5p up-regulation ameliorated the inflammatory reaction and cell barrier .damage of HSAECs induced by PAF, and inhibited the apoptosis; besides, miR-146a-5p downregulation functioned oppositely. In addition, miR-146a-5p could target TNF receptor-associated .factor 6 (TRAF6) and negatively regulate its expression. TRAF6 overexpression could counterract .the impact of miR-146a-5p up-regulation on PAF-induced inflammation, cell barrier damage and .apoptosis of HSAECs. Collectively, miR-146a-5p may protect airway epithelial cells and inhibit the .pathogenesis of asthma via targeting TRAF6.
