Cytokine producing CD8+ T cells are correlated to MRI features of tissue destruction in MS
Cytokine producing CD8+ T cells are correlated to MRI features of tissue destruction in MS
复制标题
DOI：
10.1016/s0165-5728(03)00265-0
复制
发表时间：
2003-09-01
影响因子：
3.3
通讯作者：
Polman, CH
中科院分区：
文献类型：
--
作者：
Killestein, J;Eikelenboom, MJ;Polman, CH
特定的T细胞亚群及其产生细胞因子的能力与多发性硬化（MS）发病机制有关。然而，将产生细胞因子的T细胞亚群与组织破坏的磁共振成像（MRI）特征联系起来的证据是有限的。在124名患有不同亚型MS的患者中进行了细胞因子流式细胞术。循环I型和2型辅助性T细胞产生细胞因子的能力与T1低信号和T2高信号损伤负荷（LL）的变化相关在产生IL-2、IL-4或IL-13的基线CD 8（+）T细胞亚群与T1 LL的变化之间发现显著的负相关。亚组分析表明，在RRMS中，CD 8（+）T细胞产生IL-2，IL-4或IL-13，而在PPMS中，CD 8（+）IL-10（+）T细胞与T1 LL呈负相关。据我们所知，这项研究提供了第一个直接的免疫表型证据，表明产生细胞因子的CD 8 + T细胞与脱髓鞘和轴突丢失的MRI特征的长期发展直接相关。(C)2003 Elsevier B. V.保留所有权利。
Specific T-cell subsets and their ability to produce cytokines have been involved in concepts of multiple sclerosis (MS) pathogenesis. Evidence to link cytokine producing T-cell subsets to magnetic resonance imaging (MRI) features of tissue destruction, however, is limited.Cytokine flow cytometry was performed in 124 patients with different subtypes of MS. In a subgroup of 69 patients, from whom longitudinal MRI was available, the ability of circulating types I and 2 helper T cells to produce cytokines was correlated to changes in T1 hypointense and T2 hyperintense lesion load (LL) on brain MRI during 3 years of follow-up.Significant negative correlations were found between baseline CD8(+) T-cell subsets producing IL-2, IL-4 or IL-13 and the change in T1 LL. Subgroup analyses demonstrated that in RRMS, CD8(+) T cells producing IL-2, IL-4 or IL-13, and in PPMS, CD8(+) IL-10(+) T cells correlated negatively with T1 LL.To our knowledge, this study provides the first direct immumophenotypic evidence of cytokine producing CD8+ T cells being directly related to long-term development of MRI features of demyelination and axonal loss. (C) 2003 Elsevier B.V. All rights reserved.