System identification of closed-loop cardiovascular control: effects of posture and autonomic blockade.
System identification of closed-loop cardiovascular control: effects of posture and autonomic blockade.
复制标题
闭环心血管控制的系统识别：姿势和自主神经阻滞的影响。
DOI：
10.1152/ajpheart.1997.272.1.h448
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Cohen,RJ
中科院分区：
文献类型：
--
作者：
Mullen,TJ;Appel,ML;Mukkamala,R;Mathias,JM;Cohen,RJ
我们应用系统识别的心率（HR），动脉血压（ABP）和瞬时肺容量（ILV）的波动的分析，定量表征的生理机制负责这些变量之间的耦合。我们描述了两种机械介导的耦合机制[心率压力感受器反射（HR压力感受器反射）和呼吸性窦性心律失常（ILV-HR）]和两种机械介导的耦合机制[每次心脏收缩产生的血压小波（循环力学）和呼吸对血压的直接机械效应（ILV-ABP）]。我们在对照条件下以及β-交感神经和副交感神经药理学阻断条件下，在仰卧和站立姿势研究的人体中评价了该方法。联合β-交感神经和副交感神经阻滞取消了神经介导的耦合，同时保留机械介导的耦合。选择性自主神经阻滞和姿势变化也改变了耦合的方式与已知的生理机制一致。系统识别是一种“逆建模”技术，其提供了用于为个体受试者创建心血管调节的闭环模型而不改变潜在的生理控制机制的手段。
We applied system identification to the analysis of fluctuations in heart rate (HR), arterial blood pressure (ABP), and instantaneous lung volume (ILV) to characterize quantitatively the physiological mechanisms responsible for the couplings between these variables. We characterized two autonomically mediated coupling mechanisms [the heart rate baroreflex (HR baroreflex) and respiratory sinus arrhythmia (ILV-HR)] and two mechanically mediated coupling mechanisms [the blood pressure wavelet generated with each cardiac contraction (circulatory mechanics) and the direct mechanical effects of respiration on blood pressure (ILV⇢ABP)]. We evaluated the method in humans studied in the supine and standing postures under control conditions and under conditions of beta-sympathetic and parasympathetic pharmacological blockades. Combined beta-sympathetic and parasympathetic blockade abolished the autonomically mediated couplings while preserving the mechanically mediated coupling. Selective autonomic blockade and postural changes also altered the couplings in a manner consistent with known physiological mechanisms. System identification is an “inverse-modeling” technique that provides a means for creating a closed-loop model of cardiovascular regulation for an individual subject without altering the underlying physiological control mechanisms.