Tau: The Center of a Signaling Nexus in Alzheimer's Disease.
Tau: The Center of a Signaling Nexus in Alzheimer's Disease.
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DOI：
10.3389/fnins.2016.00031
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发表时间：
2016
影响因子：
4.3
通讯作者：
Bloom GS
中科院分区：
文献类型：
--
作者：
Khan SS;Bloom GS
Tau是一种微管相关蛋白，其错误折叠、过度磷酸化、正常功能丧失和功能毒性获得与多种神经退行性疾病有关，包括阿尔茨海默病（AD）。本文综述了tau蛋白在β淀粉样蛋白（Aβ）诱导的AD毒性中的作用。tau蛋白功能障碍的后果，从轴突开始，并在somadendritic隔间结束，将突出显示。
Tau is a microtubule-associated protein whose misfolding, hyper-phosphorylation, loss of normal function and toxic gain of function are linked to several neurodegenerative disorders, including Alzheimer's disease (AD). This review discusses the role of tau in amyloid-β (Aβ) induced toxicity in AD. The consequences of tau dysfunction, starting from the axon and concluding at somadendritic compartments, will be highlighted.