Carcinoma of the cervix and the use of hyperbaric oxygen with radiotherapy: a report of a randomised controlled trial
Carcinoma of the cervix and the use of hyperbaric oxygen with radiotherapy: a report of a randomised controlled trial
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DOI：
10.1016/s0167-8140(99)00124-3
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发表时间：
1999-11-01
影响因子：
5.7
通讯作者：
Bentzen, SM
中科院分区：
文献类型：
--
作者：
Dische, S;Saunders, MI;Bentzen, SM
背景和目的：在1971年至1980年期间进行了一项高压氧放射治疗Ⅱ b期和Ⅲ期宫颈癌的随机对照试验。除了一个抽象的中期报告，在1977年，结果尚未published.Material和方法：在四臂研究，335例患者随机治疗10或28个分数，在高压氧或在空气中。数据是关于327例，这已经analysed.Results：有没有优势，在肿瘤控制显示使用高压氧。有证据表明，当在高压氧中而不是在空气中进行治疗时，以及当使用10次分割，达到45而不是40戈伊的总剂量时，晚期辐射发病率增加。对于晚期肠道疾病，计算出的分割敏感性（α/β比值）为4.3戈伊，剂量反应曲线的陡度（γ（50））为2.6。结论：高压氧对Ⅱ b期和Ⅲ期宫颈癌患者采用两种分割方案进行放射治疗均无益处。关于后期辐射发病率的重要数据已经披露。(C)1999爱思唯尔科学爱尔兰有限公司保留所有权利。
Background and purpose: A randomised controlled trial of hyperbaric oxygen in the radiotherapy of Stage IIb and III carcinoma of cervix was performed between 1971 and 1980. Apart from an abstract giving an interim report in 1977, results have not been published.Material and methods: In a four arm study, 335 patients were randomised to treatment in 10 or 28 fractions, in hyperbaric oxygen or in air. Data is available concerning 327 cases and this has been analysed.Results: There was no advantage in tumour control shown with the use of hyperbaric oxygen. There was evidence for an increase in late radiation morbidity when treatment was given in hyperbaric oxygen rather than in air and when, using 10 fractions, a total dose of 45 rather than 40 Gy was achieved. For late intestinal morbidity, the fractionation sensitivity (alpha/beta ratio) was calculated to be 4.3 Gy and the steepness of the dose response curve (gamma(50)) to be 2.6.Conclusions: Hyperbaric oxygen gave no benefit in the treatment of patients with stage IIb and III carcinoma of the cervix treated with radiotherapy using two fractionation regimes. Important data regarding late radiation morbidity has been revealed. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.