Probiotic yogurt and acidified milk similarly reduce postprandial inflammation and both alter the gut microbiota of healthy, young men
Probiotic yogurt and acidified milk similarly reduce postprandial inflammation and both alter the gut microbiota of healthy, young men
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DOI：
10.1017/s0007114517000885
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发表时间：
2017-05-01
影响因子：
3.6
通讯作者：
Vionnet, Nathalie
中科院分区：
文献类型：
--
作者：
Burton, Kathryn J.;Rosikiewicz, Marta;Vionnet, Nathalie
人们已经研究了益生菌酸奶和补充益生菌的牛奶在“低度”炎症中的作用，但其功效的证据尚无定论。这项研究探讨了益生菌酸奶对代谢和炎症生物标志物的影响，同时研究了肠道微生物群动态。这项随机交叉研究在 14 名健康年轻男性中进行，在为期 2 周的干预期间（400 克/天）测试益生菌酸奶与用 2% D-(+)-葡萄糖酸-δ-内酯酸化的牛奶进行比较。禁食评估、高脂膳食测试（HFM）和微生物群分析用于评估干预效果。 HFM 的基线评估是在提供正常牛奶的跑奶后进行的。与摄入酸化牛奶相比，饮用益生菌酸奶后对 HFM 的炎症反应没有显着差异；然而，与基线测试（通过 IL6、TNF α 和趋化因子配体 5 评估）相比，这两种产品均与 HFM 炎症反应显着降低相关（P < 0.001）。这些观察结果伴随着微生物群分类群的显着变化，包括酸化牛奶后 Bilophila wadsworthia 丰度下降（log 2 倍变化 (FC) =- 1.5，P-adj= 0.05）和益生菌酸奶摄入量（FC =- 1.3，P-adj= 0.03），酸化牛奶摄入后双歧杆菌物种丰度增加（FC= 1.4，P-adj= 0.04) 并检测德氏乳杆菌 (Lactobacillus delbrueckii spp.)。保加利亚菌（FC= 7.0，P-adj< 0.01）和唾液链球菌属。摄入益生菌酸奶后嗜热菌（FC=6.0，P-adj<0.01）。益生菌酸奶和酸化牛奶同样可以减少与 HFM 相关的餐后炎症，同时诱导健康男性肠道微生物群的明显变化。这些观察结果可能与针对“低度”炎症的饮食治疗相关。
Probiotic yogurt and milk supplemented with probiotics have been investigated for their role in 'low-grade' inflammation but evidence for their efficacy is inconclusive. This study explores the impact of probiotic yogurt on metabolic and inflammatory biomarkers, with a parallel study of gut microbiota dynamics. The randomised cross-over study was conducted in fourteen healthy, young men to test probiotic yogurt compared with milk acidified with 2% D-(+)-glucono-delta-lactone during a 2-week intervention ( 400 g/d). Fasting assessments, a high-fat meal test ( HFM) and microbiota analyses were used to assess the intervention effects. Baseline assessments for the HFM were carried out after a runin during which normal milk was provided. No significant differences in the inflammatory response to the HFM were observed after probiotic yogurt compared with acidified milk intake; however, both products were associated with significant reductions in the inflammatory response to the HFM compared with the baseline tests ( assessed by IL6, TNF alpha and chemokine ligand 5) ( P < 0 001). These observations were accompanied by significant changes in microbiota taxa, including decreased abundance of Bilophila wadsworthia after acidified milk ( log 2-fold-change ( FC) =- 1.5, P-adj= 0.05) and probiotic yogurt intake ( FC =- 1.3, P-adj= 0.03), increased abundance of Bifidobacterium species after acidified milk intake ( FC= 1.4, P-adj= 0.04) and detection of Lactobacillus delbrueckii spp. bulgaricus ( FC= 7.0, P-adj< 0.01) and Streptococcus salivarius spp. thermophilus ( FC= 6.0, P-adj< 0.01) after probiotic yogurt intake. Probiotic yogurt and acidified milk similarly reduce postprandial inflammation that is associated with a HFM while inducing distinct changes in the gut microbiota of healthy men. These observations could be relevant for dietary treatments that target 'low-grade' inflammation.