Oleoylethanolamide: A fat ally in the fight against obesity
Oleoylethanolamide: A fat ally in the fight against obesity
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DOI：
10.1016/j.physbeh.2017.02.034
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发表时间：
2017-07-01
影响因子：
2.9
通讯作者：
Ayala, Julio E.
中科院分区：
文献类型：
--
作者：
Brown, Jacob D.;Azari, Elnaz Karimian;Ayala, Julio E.
肥胖是一种流行病，在现代，久坐不动，高热量饮食的社会中蓬勃发展。如果不加以控制，肥胖和与肥胖相关的疾病将继续困扰子孙后代，给经济、医疗体系和数十亿人的生活质量带来沉重负担。亟需阐明解决这一全球卫生保健危机的基本生理机制和治疗方法。油脂乙醇酰胺（OEA）是一种内源性大麻素类脂质，可诱导啮齿动物吞咽并减少脂肪量。在过去的十多年里，ppar - α通过向体内平衡的大脑中心发送信号，成为OEA吞食作用的最广泛接受的介质。最近的证据表明，OEA也可能通过影响享乐大脑中的多巴胺和内源性大麻素信号来减少食物摄入。中心。对人体补充OEA的有限研究为基于OEA的减肥疗法提供了一些令人鼓舞的见解，但需要更彻底、更有控制的研究。作为食物摄入的内稳态和享乐调节之间的潜在联系，OEA是开发更有效的肥胖治疗方法的主要起点。(C) 2017爱思唯尔公司版权所有。
Obesity is a pandemic, gateway disease that has thrived in modem, sedentary, high calorie-eating societies. Left unchecked, obesity and obesity-related diseases will continue to plague future generations with heavy burdens on economies, healthcare systems, and the quality of life of billions. There is a significant need to elucidate basic physiological mechanisms and therapies that address this global health care crisis. Oleoylethanolamide (OEA) is an endocannabinoid-like lipid that induces hypophagia and reduces fat mass in rodents. For over a decade, PPAR-alpha has been the most widely accepted mediator of the hypophagic action of OEA via signaling to homeostatic brain centers. Recent evidence suggests that OEA may also reduce food intake via effects on dopamine and endocannabinoid signaling within hedonic brain. centers. Limited study of OEA supplementation in humans has provided some encouraging insight into OEA-based weight loss therapy, but more thorough, controlled investigations are needed. As a potential link between homeostatic and hedonic regulation of food intake, OEA is a prime starting point for the development of more effective obesity therapies. (C) 2017 Elsevier Inc. All rights reserved.