Thymus size at birth is associated with infant mortality: a community study from Guinea-Bissau
Thymus size at birth is associated with infant mortality: a community study from Guinea-Bissau
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DOI：
10.1080/080352502760069142
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发表时间：
2002-01-01
期刊：
影响因子：
3.8
通讯作者：
Lisse, I
中科院分区：
文献类型：
--
作者：
Aaby, P;Marx, C;Lisse, I
一些研究表明，胸腺萎缩与严重营养不良和发病率增加有关：然而，在死亡率高的国家，尚未对胸腺大小进行研究。本研究探讨了出生时胸腺大小和随后的死亡率在城市西非社区之间的关系。通过超声检查评估胸腺的大小作为体积估计值。胸腺指数共有278名儿童在比绍班迪姆的当地保健中心出生。几内亚比索.参加了这项研究。儿童随访至2岁。出生时的胸部大小与体重的关系最为密切。在控制体重和其他危险因素的情况下，男孩的胸腺指数大于女孩[平均比值（MR）= 1.07]。95%置信区间（95% CI）1.01-1.14）]。甲状腺大小也与早产有关。族群。季节和调查员但不是出生顺序母亲的年龄。社会经济因素或卫生服务的使用。婴儿死亡率为117/1000。在多元分析中。排除早产儿并调整年龄和性别。种族群体、出生季节和调查员。较高的出生体重（MR=0.35，95%CI 0.16-0.74）和较大的胸腺大小（MR 0.17，95%CI 0.06-0.48）与较低的婴儿死亡率独立相关。当两个指数在同一模型中估计时。胸腺指数与婴儿死亡率相关（MR=0.27，95% CI 0.07-1.00），而出生体重无显著影响（MR = 0.59。95% Cl 0.24-1.47）。1岁后，出生体重和胸腺大小与死亡率无关。结论：由于感染性疾病导致的所有死亡。出生时胸腺大小可能是免疫能力的重要预测因子。未来的研究应探讨胸腺生长的决定因素。
A few studies have suggested that thymus atrophy is associated with severe malnutrition and increased morbidity: however, no study of thymus size has been undertaken in countries with high mortality. This study examined the relation between thymus size at birth and subsequent mortality in an urban West African community. The size of the thymus was assessed by sonography as a volume estimate. the thymus index. A total of 278 children born at the local health centre in Bandim in Bissau. Guinea-Bissau. was enrolled in the study. Children were followed to the age of 2 y. Thymus size at birth was associated with most strongly weight. as well as with length and arm circumference, Controlling, for weight and other risk factors, boys had larger thymus indices than girls [means ratio (MR) = 1.07. 95% confidence interval (95% CI) 1.01-1.14)]. Thymus size was also associated with prematurity. ethnic group. season and investigator. but not with birth order. mother's age. socioeconomic factors or the use of health services. Infant mortality was 117/1000. In it multivariate analysis. excluding premature infants and adjusting for age, gender. ethnic group, season of birth and investigator. higher birthweight (MR=0.35, 95% Cl 0.16-0.74) and larger thymus size (MR 0.17.95% Cl 0.06-0.48) were independently associated with lower infant mortality. When both indices were estimated in the same model. the thymus index was associated with infant mortality (MR=0.27, 95% CI 0.07-1.00), whereas birthweight had a non-significant effect (MR = 0.59. 95% Cl 0.24-1.47). After 1 y of age neither birthweight nor thymus size at birth was associated with mortality.Conclusion: As all deaths Acre due to infectious diseases. thymus size at birth may be an important predictor of immune competence. Future studies should examine the determinants of thymus growth.