Male and female isoenzymes of steroid 5alpha-reductase.
Male and female isoenzymes of steroid 5alpha-reductase.
复制标题
类固醇 5α-还原酶的男性和女性同工酶。
DOI：
10.1530/ror.0.0040179
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发表时间：
1999
期刊：
影响因子：
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通讯作者：
D. Russell
中科院分区：
文献类型：
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作者：
M. Mahendroo;D. Russell
在哺乳动物中有两种类固醇5 α-还原酶同工酶，命名为1型和2型，最近的实验表明，每一种都发挥着独特的生理作用。在这篇文章中，假设1型基因指定一个女性同工酶，而2型基因指定一个男性同工酶。这一想法源于以下观察。首先，小鼠5 α-还原酶1型基因的突变通过降低生育力和阻断分娩来影响雌性的生殖，但对雄性的生殖没有影响。第二，小鼠和男性中5 α-还原酶2型基因的突变阻止了适当的男性化，但不影响女性的发育或生殖功能。这些不同的表型分析表明，同工酶催化类固醇激素代谢的合成代谢和分解代谢反应。
There are two steroid 5alpha-reductase isoenzymes, designated type 1 and type 2, in mammals and recent experiments show that each plays a unique physiological role. In this article, the hypothesis is developed that the type 1 gene specifies a female isoenzyme, whereas the type 2 gene specifies a male isoenzyme. This idea results from the following observations. First, mutation of the 5alpha-reductase type 1 gene in mice affects reproduction in females by decreasing fecundity and blocking parturition, but has no effect on reproduction in males. Second, mutation of the 5alpha-reductase type 2 gene in mice and men prevents proper virilization but does not affect development or reproductive function in females. Analyses of these diverse phenotypes indicate that the isoenzymes catalyse both anabolic and catabolic reactions in steroid hormone metabolism.
影响因子：
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作者：
M. Mahendroo;Amina Porter;D. Russell;R. Word
通讯作者：
M. Mahendroo;Amina Porter;D. Russell;R. Word