Breath analysis of ammonia, volatile organic compounds and deuterated water vapor in chronic kidney disease and during dialysis
Breath analysis of ammonia, volatile organic compounds and deuterated water vapor in chronic kidney disease and during dialysis
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DOI：
10.4155/bio.13.320
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发表时间：
2014-03-01
期刊：
影响因子：
1.8
通讯作者：
Goodwin, Lee
中科院分区：
文献类型：
--
作者：
Mannu, Ranbir S.;Turpin, Phillip E.;Goodwin, Lee
健康个体和患者（例如晚期慢性肾脏疾病患者）呼出的微量挥发性代谢物现在可以通过敏感的分析技术进行检测和量化。在这篇综述中，特别关注透析依赖性CKD 5期产生的主要滞留代谢物，特别是氨，作为尿毒症严重程度的潜在评估指标。然而，其他生物标志物也很重要，包括碳氢化合物异戊二烯、乙烷和戊烷，因为它们可能表明与透析治疗本身相关的组织损伤。过度水合是CKD 5期的一个严重并发症，在摄入了已知数量的氘水后，可以通过分析呼出的水蒸气中的氘来改善对过度水合的评估，从而在床边提供全身水分的测量，以支持临床对体积状态的管理。健康个体和患者（例如晚期慢性肾脏疾病患者）呼出的微量挥发性代谢物现在可以通过敏感的分析技术进行检测和量化。在这篇综述中，特别关注透析依赖性CKD 5期产生的主要滞留代谢物，特别是氨，作为尿毒症严重程度的潜在评估指标。然而，其他生物标志物也很重要，包括碳氢化合物异戊二烯、乙烷和戊烷，因为它们可能表明与透析治疗本身相关的组织损伤。过度水合是CKD 5期的一个严重并发症，在摄入了已知数量的氘水后，可以通过分析呼出的水蒸气中的氘来改善对过度水合的评估，从而在床边提供全身水分的测量，以支持临床对体积状态的管理。
The volatile metabolites present in trace amounts in exhaled breath of healthy individuals and patients, for example those with advanced chronic kidney disease (CKD), can now be detected and quantified by sensitive analytical techniques. In this review, special attention is given to the major retention metabolites resulting from dialysis-dependent CKD stage 5 and especially ammonia, as a potential estimator of the severity of uremia. However, other biomarkers are important, including the hydrocarbons isoprene, ethane and pentane, in that they are likely to indicate tissue injury associated with the dialysis treatment itself. Evaluation of over-hydration, a serious complication of CKD stage5 can be improved by analysis of deuterium in exhaled water vapor after ingestion of a known amount of deuterated water, so providing total body water measurements at the bedside to support clinical management of volume status.The volatile metabolites present in trace amounts in exhaled breath of healthy individuals and patients, for example those with advanced chronic kidney disease (CKD), can now be detected and quantified by sensitive analytical techniques. In this review, special attention is given to the major retention metabolites resulting from dialysis-dependent CKD stage 5 and especially ammonia, as a potential estimator of the severity of uremia. However, other biomarkers are important, including the hydrocarbons isoprene, ethane and pentane, in that they are likely to indicate tissue injury associated with the dialysis treatment itself. Evaluation of over-hydration, a serious complication of CKD stage5 can be improved by analysis of deuterium in exhaled water vapor after ingestion of a known amount of deuterated water, so providing total body water measurements at the bedside to support clinical management of volume status.