Polydatin ameliorates renal injury by attenuating oxidative stress-related inflammatory responses in fructose-induced urate nephropathic mice
Polydatin ameliorates renal injury by attenuating oxidative stress-related inflammatory responses in fructose-induced urate nephropathic mice
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虎杖甙通过减轻果糖诱导的尿酸盐肾病小鼠氧化应激相关的炎症反应来改善肾损伤
DOI：
10.1016/j.fct.2012.10.037
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发表时间：
2013-02-01
影响因子：
4.3
通讯作者：
Deng, Xukun
中科院分区：
文献类型：
--
作者：
Chen, Lvyi;Lan, Zhou;Deng, Xukun
近年来的一系列研究表明，氧化应激、核因子-κ B（NF-κ B）活化以及随后的协同炎症反应在尿酸盐肾病（UN）的发病机制中起重要作用。白藜芦醇苷具有抗氧化、抗炎和肾脏保护作用。然而，虎杖苷对UN可能的保护和有益作用尚未完全阐明。因此，我们研究了虎杖苷对UN的潜在有益作用和可能的机制。虎杖苷具有抑制黄嘌呤氧化酶的活性，在体内外均能抑制血尿酸水平。进一步的研究表明，虎杖苷表现出轻微的毒性作用，并显着改善果糖诱导的UN小鼠的肾功能。虎杖苷的肾保护作用不仅与其显著减轻尿酸诱导的氧化应激有关，还与其显著抑制氧化应激相关的炎症级联反应有关，包括降低NF-κ B B p65、考克斯-2和iNOS蛋白的表达，抑制TNF-α、PGE（2）和IL-1 β的产生。这些结果说明虎杖苷具有显著的肾保护作用和较低的毒性作用。(C)2012爱思唯尔有限公司保留所有权利。
A series of studies have recently demonstrated that the oxidative stress, nuclear factor-kappa B (NF-kappa B) activation and the subsequent coordinated inflammatory responses played an important role in the pathogenesis of urate nephropathy (UN). Polydatin has been suggested to have the properties of anti-oxidative, anti-inflammatory and nephroprotective effects. However, the possible protective and beneficial effects of polydatin on UN are not fully elucidated. Therefore, we investigated the potential beneficial effects and possible mechanisms of polydatin on UN. In this study, polydatin showed inhibitory activities on xanthine oxidase to repress the level of serum uric acid in vivo and in vitro. Further investigations revealed that polydatin displayed little toxic effects and significantly ameliorated the renal function in fructose-induced UN mice. The nephroprotective activities of polydatin was not only due to the effects on remarkably attenuating the oxidative stress induced by uric acid, but also on markedly suppressing the oxidative stress-related inflammatory cascade, including decreasing the expressions of NF-kappa B p65, COX-2 and iNOS proteins and inhibiting the productions of TNF-alpha, PGE(2) and IL-1 beta. These findings elucidated that polydatin exhibited prominent nephroprotective activities and low toxic effects. (C) 2012 Elsevier Ltd. All rights reserved.