Dynamic response of adhesion complexes:: Beyond the single-path picture -: art. no. 051910
Dynamic response of adhesion complexes:: Beyond the single-path picture -: art. no. 051910
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DOI：
10.1103/physreve.65.051910
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发表时间：
2002-05-01
影响因子：
2.4
通讯作者：
Ajdari, A
中科院分区：
文献类型：
--
作者：
Bartolo, D;Derényi, I;Ajdari, A
我们分析了分子粘附复合物对增加的拉力（动态力谱）的反应，当解离可以沿着两个选择中的任何一个发生时。在潜在的多维能量中的轨迹。景观。发现解束缚力和时间作为拉力增加速率的函数具有很大的多样性（例如，非单调性）。我们特别发现了一类“鱼叉”贴纸，它很容易粘合，但能有效地抵抗强拉力。利用现有的数据，我们也证明了从这种单分子拉扯实验中明确确定能量景观特征的随之而来的困难。
We analyze the response of molecular adhesion complexes to increasing pulling forces (dynamic force spectroscopy) when dissociation can occur along either one of two alternative. trajectories in the underlying multidimensional energy. landscape. A great diversity of behaviors (e.g., nonmonotonicity) is found for the unbinding force and time as a function of the rate at which the pulling force is increased. In particular we identify a class of "harpoon" stickers that bind easily but resist strong pulling efficiently. Using existing data, we also demonstrate the consequent difficulty of unambiguously determining the features of the energy landscape from such single-molecule pulling experiments.